Systeme und Verfahren zur Schnellen Quantitativen Nmr-Spektrumserfassung

Details

Veröffentlichungs-Nr.

EP4502636

Aktenzeichen

EP23189885

Anmeldetag

4. August 2023

Veröffentlichung

1. Oktober 2025

Erteilung

1. Oktober 2025

Rechtsraum

EP

IPC

G01R33/46

Abstract

A system, method and computer program product are disclosed for fast quantitative NMR data acquisition for a plurality of NMR scans performed on a sample. The method performs a plurality of scan batches (B1 to B3) on the sample. Each batch comprises a long delay scan (LDS) performed after a long delay interval ensuring near-full relaxation of said nuclei, followed by a set of short delay scans (SDS*), each short delay scan performed after a short delay interval smaller than the long delay interval. Each scan is associated with a corresponding scan time point (t1 to t6) in relation to the long delay scan time point of the respective scan batch. For each corresponding scan time point, aggregated NMR spectrum portions (Saa to Saf) are determined showing a decay over time. The decay is fitted with an exponential decay function (610). An averaged integral loss is computed for each scan time point. For each NMR spectrum of the scan batches, an integral associated with a respective region of interest is multiplied with a corresponding correction factor. The integrals associated with the corrected NMR spectra in all batches (B1 to B3) are summed up to obtain a representation of the NMR signal intensity in the region of interest for said sample.

Anmelder

Firma

Bruker Biospin GmbH & Co. KG

Land

🇩🇪 Deutschland

Fachgebiete