Verfahren zur Behandlung von Muskelschwund und Knochenerkrankung unter Verwendung Neuartiger Hybrider Actriib-Ligand-Trap-Proteine

Details

Veröffentlichungs-Nr.

EP4714967

Anmeldetag

19. Oktober 2017

Veröffentlichung

25. März 2026

Rechtsraum

EP

IPC

C07K14/71(ACCELERON PHARMA INC et al.)(SEEHRA JASBIR et al.)(KNOPF JOHN et al.)(ALIVEGEN USA INC et al.)(SUN JEONGHOON et al.)

Abstract

The present disclosure describes novel hybrid soluble ActRIIB-ECD polypeptides which fully retain binding affinity for myostatin and activin A but demonstrate significantly reduced binding to BMPs, especially BMP-9. The novel compositions described herein can be used to prepare novel hybrid ActRIIB ligand trap proteins, which can be used for modulating the growth of muscle, bone, cartilage, fat, fibroblast, blood and neuronal tissue to counteract muscle wasting, bone loss, anemia, inflammation and fibrosis in a therapeutically meaningful manner. Because these novel next-generation myostatin/activin inhibitors are safer and more effective molecules than the currently available myostatin inhibitors, they are useful in a wide variety of clinical indications.

Anmelder

Firma

AliveGen Inc.

Land

🇰🇾 KY

Fachgebiete