Verfahren zur Herstellung eines Antikörper-Wirkstoff-Konjugats mit Reinigungsschritt unter Verwendung von Aktivkohlematerial

Details

Veröffentlichungs-Nr.

EP4737483

Anmeldetag

28. Juni 2024

Veröffentlichung

2. Januar 2025

Rechtsraum

EP

Abstract

Provided is a method for producing an antibody-drug conjugate that includes a purification process for efficiently removing by-product(s) derived from an exatecan compound. Provided is a method for producing an antibody-drug conjugate, in which a drug-linker represented by the following formula, wherein A represents the connecting position to an antibody, and the antibody are conjugated via a thioether bond, the method including the step of: (i) removing, from a solution containing the antibody-drug conjugate, byproduct(s) derived from an exatecan compound contained in the solution by using an activated carbon material.

Anmelder

Firma

Daiichi Sankyo Company, Limited

Land

🇯🇵 Japan