Glucocorticoidrezeptormodulatoren zur Behandlung von Bauchspeicheldrüsenkrebs
Anmelder: Corcept Therapeutics, Inc. 🇺🇸
Details
- Veröffentlichungs-Nr.
- EP4772249
- Anmeldetag
- 8. September 2017
- Veröffentlichung
- 8. Juli 2026
- Rechtsraum
- EP
- IPC
- A61P43/00
Abstract
Methods and compositions for treating a subject hosting a non-ACTH-secreting pancreatic tumor are disclosed. The methods include administering to the subject a chemotherapeutic agent and a glucocorticoid receptor modulator (GRM), preferably a selective glucocorticoid receptor modulator (SGRM), to reduce the tumor load in the subject. The GRM may be a nonsteroidal GRM, and may be a nonsteroidal SGRM. The non-ACTH-secreting pancreatic tumor may be an exocrine pancreatic tumor. The nonsteroidal SGRM may be a nonsteroidal compound comprising: a fused azadecalin structure; a heteroaryl ketone fused azadecalin structure; or an octahydro fused azadecalin structure. Pharmaceutical compositions comprising a chemotherapeutic agent and a GRM are disclosed. The GRM in such pharmaceutical compositions may be a nonsteroidal GRM, and may be a SGRM, such as a nonsteroidal SGRM. The nonsteroidal SGRM may comprise: a fused azadecalin structure; a heteroaryl ketone fused azadecalin structure; or an octahydro fused azadecalin structure.
Anmelder
- Firma
- Corcept Therapeutics, Inc.
- Land
- 🇺🇸 USA
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