Auf Menschliches CD153 Abzielender Antikörper und Chimärer Antigenrezeptor

Details

Veröffentlichungs-Nr.

EP4790069

Anmeldetag

2. Oktober 2024

Veröffentlichung

10. April 2025

Rechtsraum

EP

Abstract

The present application provides an anti-human CD153 monoclonal antibody, or a binding fragment thereof, which specifically binds to human CD153 and inhibits the intermolecular interaction between human CD153 and CD30. The present application further provides a chimeric antigen receptor comprising an extracellular antigen-binding domain, a transmembrane domain, and an intracellular signaling domain, wherein the extracellular antigen-binding domain comprises a single-chain antibody having the same heavy chain hypervariable regions and light chain hypervariable regions as those of the monoclonal antibody of the present application, and a CAR-T cell expressing the chimeric antigen receptor. The monoclonal antibody, the binding fragment thereof, and the CAR-T cell of the present application are useful for the treatment or prevention of diseases associated with CD153, such as multiple sclerosis.

Anmelder

Firmen

Kyoto University
Cyn-K Bio, Inc.

Land

🇯🇵 Japan