Auslösung Hochauflösender Massenspektrometeranalysen Isobar Markierter Reporterionen

Details

Veröffentlichungs-Nr.

EP4804232

Anmeldetag

3. März 2026

Veröffentlichung

9. September 2026

Rechtsraum

EP

IPC

H01J49/00, G01N33/68

Abstract

A method of mass analyzing analytes within a mixture of samples, wherein all analytes from each sample from which the mixture is derived comprise a same isotopic label and wherein a different unique isotopic label is associated with each respective sample, the method comprising: cleaving, within the mass spectrometer, a reporter ion species from ions of an analyte of the mixture, wherein the reporter ion species comprises all of the isotopic labels from each of the differently-labeled samples; mass analyzing the reporter ion species at a first mass-spectral resolution; comparing an observed pattern of intensities of the mass analyzed reporter ion species to a predetermined intensity pattern; and if the observed intensity pattern fails to match the predetermined intensity pattern, mass analyzing the reporter ion species at a second mass spectral resolution that is greater than the first resolution.

Anmelder

Firma

Thermo Finnigan LLC

Land

🇺🇸 USA

Fachgebiete