Neuartige Peptide mit Spezifität für Enthothelzellen

Details

Veröffentlichungs-Nr.

EP4806450

Anmeldetag

10. März 2025

Veröffentlichung

16. September 2026

Rechtsraum

EP

Abstract

The invention relates to a peptide, polypeptide, or protein that binds specifically to endothelial cells. The peptide, polypeptide, or protein can be a component of a viral capsid and can be used to target a recombinant viral vector selectively to endothelial tissue after systemic administration to a subject and to ensure expression of one or more transgenes in well-perfused organs, such as the brain, the heart, the kidney, the lung, the liver and the spleen. The invention thus further relates to a recombinant viral vector, preferably an AAV vector, which comprises a capsid containing the peptide, polypeptide, or protein according to the invention and which comprises at least one transgene packaged in the capsid. The viral vector is suitable in particular for the therapeutic treatment of a vascular or metabolic disorder or a vascular or metabolic disease. The invention further relates to cells and pharmaceutical compositions which comprise the viral vector according to the invention.

Anmelder

Firmen

Universitätsklinikum Hamburg-Eppendorf
Universität zu Lübeck
Universität Augsburg, in Vertretung des Freistaates Bayern

Land

🇩🇪 Deutschland