Protokoll zur Homologen Reihenidentifizierung und Analyse in Lc-Ms/ms-Experimenten
Anmelder: Bruker Daltonics GmbH & Co. KG 🇩🇪
Details
- Veröffentlichungs-Nr.
- EP4819192
- Anmeldetag
- 1. April 2025
- Veröffentlichung
- 7. Oktober 2026
- Rechtsraum
- EP
- IPC
- H01J49/00, G01N33/68
Abstract
Method for the identification of molecular changes between homologous rows of analytes of a first sample and of a second sample different from the first sample, analyzed by using untargeted LC MS/MS experiments. The method comprises the following steps: i) identifying analytes and isotope patterns in the samples; ii) annotating said analytes, by using a spectral library, rule-based annotation or simulations; iii) calculating the change of intensity of each annotated analyte, preferably as the binary logarithm of such a ratio; iv) sorting the data of the analytes as a function of said at least one repeating structural feature and thereby identifying analytes with differential behavior within homologous rows of analytes in said samples ; v) scheduling a targeted LC MS/MS of the first and/or the second sample for the identified analytes.
Anmelder
- Firma
- Bruker Daltonics GmbH & Co. KG
- Land
- 🇩🇪 Deutschland
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