Linsmeier, Josef

The disclosure relates to a device and a corresponding method for detecting particles, in particular microparticles, bioparticles, single cells or cell clusters, contained in a liquid. The device comprising an irradiation device configured to irradiate a volume of the liquid with time-varying, in particular pulsed or modulated, electromagnetic radiation, and at least one focused interdigital transducer (fIDT) configured to detect surface acoustic waves emanating from particles contained in the liquid in response to irradiating the volume of the liquid with the electromagnetic radiation, wherein the at least one focused interdigital transducer has a focal point or focal area and is preferably arranged such that the focal point or focal area of the focused interdigital transducer is located at or close to the irradiated volume of the liquid containing the particles. The disclosure allows for a sensitive detection of opto-acoustic waves emanating from particles contained in the liquid with a spatial resolution or spatial selectivity in the order of the particle diameter, and further enables a reproducible, precise, miniaturized and/or parallelized design of the device.

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The disclosure relates to a handheld device (1) and system for optoacoustic imaging of an object (3), the device (1) comprising a housing (2) configured to be grasped by an operator's hand and guided and/or positioned by the operator relative to the object (3) during imaging, wherein the following components are integrated in and/or provided on the housing: a) an illumination unit (4, 6) configured to illuminate the object (3) with time-varying electromagnetic radiation (5), the illumination unit (4, 6) comprising at least one radiation source (4, 6), in particular at least one laser diode (LD), vertical-cavity surface-emitting laser (VCSEL) or light-emitting diode (LED), having a front side (4a) and a back side (4b) opposite the front side and configured to emit the electromagnetic radiation (5) at the front side (4a) of the at least one radiation source (4), the illumination unit (4, 6) further comprising a first electronic controller (6) provided at the back side (4b) of and/or close to the at least one radiation source (4) and configured to control the at least one radiation source (4) to emit pulses of electromagnetic radiation (5) exhibiting at least one of a predefined electromagnetic spectrum and/or wavelength(s), pulse amplitude, pulse shape, pulse width (duration) and/or pulse repetition rate, and b) a detection unit (7, 9) configured to detect ultrasonic waves (8) emanating from the object (3) in response to illuminating the object (3) with the time-varying electromagnetic radiation (5), the detection unit (7, 9) comprising at least one ultrasonic transducer (7), in particular at least one micromachined ultrasonic transducer (MUT) and/or at least one piezoelectric ultrasonic transducer (PUT), having a front side (7a) and a back side (7b) opposite the front side and configured to convert ultrasonic waves (8) impinging at the front side (7a) of the at least one ultrasonic transducer (7) into detection signals, the detection unit (7, 9) further comprising a second electronic controller (9) provided at the back side (7b) of the at least one ultrasonic transducer (7) and configured to process the detection signals, in particular to digitize and/or filter the detection signals and to reconstruct an image of the object (3) based on the digitized and/or filtered detection signals.

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The invention relates to a method and a corresponding system for providing medical information from a plurality of data sources (1), in particular healthcare organizations such as hospitals and/or medical offices, to a plurality of data users (4, 10), in particular clinical researchers and/or research institutions. The system comprises: a) a plurality of first processing appliances (2) each operatively coupled to a respective data source (1), each first processing appliance (2) being configured to i) retrieve and/or receive from the respective data source (1), one or more electronic medical records (5), each electronic medical record (5) containing data associated with an individual patient, and ii) to generate, for each electronic medical record (5), a metadata record (MDR) by labeling data contained in the respective electronic medical record (5) with metadata regarding a plurality of different categories including at least one of the following patient-related categories: date or year of birth, age, location, disease, allergy, medication, observations and/or procedures a patient has undergone, and including, in the metadata record (MDR), metadata and therewith labeled data in accordance with a predefined list (whitelist) of metadata to be included, while excluding and/or obfuscating data and/or metadata in accordance with at least one predefined condition ("blocklfRare", "blocklfAge>95") for at least one of the patient-related categories of metadata and therewith labeled data; b) at least one first storage appliance (6) configured to retrieve and/or receive the metadata records (MDR) from the first processing appliances (2) and to store the retrieved and/or received metadata records (MDR); and c) at least one access control appliance (9) configured to control, in particular to grant and/or deny, access of the data users (4, 10) to the first storage appliance (9).

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