Bioaktive Hydroxyapatitmaterialien, die mit Pyomelanin Modifiziert Sind, Polymerkeramische Biokomposite mit Pyomelanin-Hydroxyapatit, Verfahren zu Ihrer Herstellung und Ihre Verwendung

Details

Veröffentlichungs-Nr.

EP4751742

Anmeldetag

19. November 2025

Veröffentlichung

3. Juni 2026

Rechtsraum

EP

Abstract

The subject of the invention is a pyomelanin-modified hydroxyapatite for the production of bioactive polymer composites, the surface of which is chemically modified by pyomelanin molecules covalently attached via a silane precursor or by pyomelanin molecules incorporated in an in situ reaction between the hydroxyapatite crystal lattice and three-component polymer-ceramic biocomposites with osteoconductive, immunomodulating and antibacterial properties produced in the form of flexible porous materials based on poly(glycerol adipate) (PGA) containing as a ceramic phase one of the selected pyomelanin-modified hydroxyapatites (HA): nHA-PyoM in situ or nHA-APTES-PyoM and calcined nanohydroxyapatite (nHA1200°C) for use, in particular in bone tissue implant materials. The subject of the invention also includes methods for obtaining hydroxyapatite and biocomposites and their use for filling bone defects and for bone regeneration, and more specifically for dental, veterinary and orthopedic implantations, including bone oncology.

Anmelder

Firmen

Uniwersytet Lodzki
Siec Badawcza Lukasiewicz - Instytut Ceramiki i Materialow Budowlanych
Politechnika Wroclawska

Land

🇵🇱 Polen