Godlewski, Piotr

The present invention relates to a method for enhancing the security and integrity of Proof-of-Work (PoW) systems in blockchain networks. Traditional PoW validation relies on verifying a valid nonce, but this approach is vulnerable to manipulation, as it does not independently confirm the entire computational process. The invention proposes a novel solution that securely validates the full PoW computation, ensuring that miners perform the intended algorithmic steps rather than exploiting shortcuts or using nonces derived from different algorithms. By embedding cryptographic proofs within the PoW verification process, the invention prevents tampering and manipulation, enhancing the transparency, security, and trustworthiness of PoW-based blockchain systems. This method strengthens the consensus mechanism and protects the network from malicious actors, ensuring the integrity of the blockchain.

The subject of the invention is a pyomelanin-modified hydroxyapatite for the production of bioactive polymer composites, the surface of which is chemically modified by pyomelanin molecules covalently attached via a silane precursor or by pyomelanin molecules incorporated in an in situ reaction between the hydroxyapatite crystal lattice and three-component polymer-ceramic biocomposites with osteoconductive, immunomodulating and antibacterial properties produced in the form of flexible porous materials based on poly(glycerol adipate) (PGA) containing as a ceramic phase one of the selected pyomelanin-modified hydroxyapatites (HA): nHA-PyoM in situ or nHA-APTES-PyoM and calcined nanohydroxyapatite (nHA1200°C) for use, in particular in bone tissue implant materials. The subject of the invention also includes methods for obtaining hydroxyapatite and biocomposites and their use for filling bone defects and for bone regeneration, and more specifically for dental, veterinary and orthopedic implantations, including bone oncology.

The invention provides a pharmaceutical composition comprising IM2 peptide of SEQ ID NO: 1 and NE1 peptide of SEQ ID NO: 2, and at least one pharmaceutically acceptable excipient, and its use.

The subject of the invention is a herbal and mineral composition for the treatment of inflammation, with analgesic, anti-oedema, astringent, anticoagulant and anti-clotting properties, for external application to the patient's skin, containing aluminium salts, calendula extract and arnica extract, wherein arnica contains sesquiterpene lactones and the flavonoid fraction of arnica, additionally containing substances that delay clot formation and/or substances that dissolve existing clots, selected from substances with anti-aggregating, anticoagulant, fibrinolytic, thrombolytic and substances that reduce the number of coagulation factors. The subject of the invention is also the use of the described composition for treating inflammation, pain and swelling.

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The invention concerns a diagnostic kit for diagnosing urinary tract infections, especially in patients particularly exposed to the development of UTI complications, and a method of in vitro diagnosing of urinary tract infections in a sample, performed using the kit.