Verfahren zur Bestimmung von Amphetamin in Gegenwart von Koffein und Paracetamol

Details

Veröffentlichungs-Nr.

EP4800385

Anmeldetag

27. Februar 2026

Veröffentlichung

2. September 2026

Rechtsraum

EP

IPC

G01N27/48, // G01N27/403

Abstract

The present invention relates to a rapid, simple, quantitative and qualitative method for the determination of amphetamine. The method is characterized in that two pairs of electrodes are introduced into an appropriately designed electrochemical cell comprising two parts, respectively filled with an organic phase being a solution of a supporting electrolyte and an aqueous phase containing a solution of a supporting electrolyte that dissociates into ions with a low partition coefficient. One pair of reference electrodes in the form of a wire coated with Ag/AgCl and one pair of auxiliary electrodes made of platinum. All the electrodes are then connected to a potentiostat, which enables potentiostatic polarisation of the liquid-liquid interface. The amphetamine sample under investigation is dissolved in the aqueous phase containing a solution of a supporting electrolyte with a pH below the pKa of amphetamine, and its controlled interfacial transfer across the liquid-liquid interface occurs. The transfer of an amphetamine molecule is recorded using electroanalytical methods such as voltammetry. The value of the potential applied from an external polarisation source provides qualitative information, whilst the Faraday currents recorded provide quantitative information. The determination of the concentration of the amphetamine being tested is based on standard calibration methods.

Anmelder

Firma

Uniwersytet Lodzki

Land

🇵🇱 Polen

Fachgebiete