Kicinska-Fujawa, Alicja

The invention relates to a method of manufacturing microparticles containing Mycobacterium bovis BCG vaccine bacilli encapsulated in an alginate carrier, intended for combating Helicobacter pylori infection, characterised in that an aqueous solution of a non-ionic copolymeric surfactant (C₃H₆O.C₂H₄O)_X and/or a solution of chitosan in 1% acetic acid, and a suspension of live M. bovis BCG in 1 mL of saline solution with a BCG density of 3×10⁹ CFU/mL, and then subjected to a microencapsulation procedure by adding the above-mentioned solutions dropwise, using a 2 mL syringe, to a vessel containing a 0.5% calcium chloride solution, at room temperature on a magnetic stirrer for 1 hour. After one hour, the microcapsules are drained using a laboratory sieve and rinsed with sterile distilled water, using chitosans with a molecular weight in the range of 50.000-190.000 g/mol or 190.000-310.000 g/mol or 310.000-375.000 g/mol, with the concentration of the polymer solution used to prepare the alginate microcapsules being 2% v/v for alginate, 1% v/v for chitosan and 12 600 g/mol for the non-ionic copolymer surfactant (C₃H₆O.C₂H₄O)x.

The present invention relates to a rapid, simple, quantitative and qualitative method for the determination of amphetamine. The method is characterized in that two pairs of electrodes are introduced into an appropriately designed electrochemical cell comprising two parts, respectively filled with an organic phase being a solution of a supporting electrolyte and an aqueous phase containing a solution of a supporting electrolyte that dissociates into ions with a low partition coefficient. One pair of reference electrodes in the form of a wire coated with Ag/AgCl and one pair of auxiliary electrodes made of platinum. All the electrodes are then connected to a potentiostat, which enables potentiostatic polarisation of the liquid-liquid interface. The amphetamine sample under investigation is dissolved in the aqueous phase containing a solution of a supporting electrolyte with a pH below the pKa of amphetamine, and its controlled interfacial transfer across the liquid-liquid interface occurs. The transfer of an amphetamine molecule is recorded using electroanalytical methods such as voltammetry. The value of the potential applied from an external polarisation source provides qualitative information, whilst the Faraday currents recorded provide quantitative information. The determination of the concentration of the amphetamine being tested is based on standard calibration methods.

The present application belongs to the technical field of synthesis of fluorine-containing fine chemicals and specifically relates to an oxa-hydrofluoroether compound and a synthesis method and a use thereof. An oxa-hydrofluoroether compound, having a structure as shown in Formula (1): <img class="EMIRef" id="114dc869-d79d-4c1c-84ef-80a8ba59ef5b-ia01" /> wherein, R<f> is F or CF<3>; R is methyl or ethyl; n is an integer of 1-3. For the oxa-hydrofluoroether compound disclosed in the present application, due to the embedding of oxygen atoms in the fluorocarbon chain structure, the fluorine-containing segments of hydrofluoroether are more diversified, such that the structure is no longer limited to a perfluorocarbon chain structure. In such an oxa-hydrofluoroether compound, the oxygen atoms play a role in reducing the surface tension, and the more oxygen atoms the oxa-hydrofluoroether compound contains, the lower the surface tension. Compared with other hydrofluoroether solvents, the oxa-hydrofluoroether compound exhibits stronger permeability and better cleaning performance. Due to the embedding of oxygen atoms into the fluorocarbon chain structure and the presence of branched fluorocarbon segments, the oxa-hydrofluoroether compound is more readily degradable, thereby improving environmental friendliness.

The object of the invention is tryptophan or metabolite thereof from the kynurenine pathway selected from a group comprising 3-hydroxykynurenin, quinolinic acid, kynurenic acid, quinaldic acid and picolinic acid for use in the prevention or treatment of dermatophytoses, especially caused by Trichophyton rubrum and composition, preferably in the form of nail polish.

The object of the invention is a universal bracket for fastening flat elements with large surface areas, especially photovoltaic panels, to seamed roof slopes, consisting of several detachable elements comprising a body, an overlay and a clamping element, wherein consists of a body (1) having an H-shape, the lower arms of which form a rectangular projection, where one of the lower arms is provided with a socket for a screw (5), in the central part between the arms of the body (1) there is a rectangular boss with a T-shaped hole, where an adapter (3) with nuts is inserted, and at least one U-shaped cap (2), the first arm of which has an outward-facing edge forming a bend matching in size the height of the groove formed by the edge of the upper arm of the body (1), while the second arm of the cap (2) is turned inwards in such a way that with the vertical part of the second arm it forms a hole in the shape of a right triangle, the base of which is located in the upper part of the cap and forms a support (P) for the attachment of the photovoltaic panel, and a clamping element (4) of trapezoidal shape, which has symmetrically shaped arms of triangular shape or the clamping element (4) has one arm of triangular shape, and the other arm has an inverted L-shape, the clamping element (4) having in its central part a rectangular finial connecting the two arms of the clamping element (4), the finial having holes or recesses, the arrangement of which corresponds to the position of the holes of the adapter (3) and which are intended to connect the clamping element (4) to the photovoltaic panel and the cap (2) by means of screws (6).

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Zusammenfassung wird geladen …

Zusammenfassung wird geladen …

Zusammenfassung wird geladen …

Zusammenfassung wird geladen …