Consejo Superior de Investigaciones Científicas

The invention discloses a polypeptide with hyaluronidase activity from Purpureocillium sp, comprising the amino acid sequence in SEQ. ID. No. 1 or a variant thereof, a polynucleotide comprising said polypeptide, a recombinant vector, a host cell and a method to produce the polypeptide of SEQ. ID. No. 1 or a variant thereof and its use to produce a mixture of hyaluronan oligosaccharides.

The present invention discloses a device (1) for receiving an initial sequence (2) of polarized photons, modifying the polarization of each of said photons and performing measurements upon each of said photons according to an embodiment of the present invention. The device (1) comprises a beam splitter (3); two half-wave plates (4, 4'), two quarter-wave plates (5, 5'); two polarizer beam splitters (6, 6'), four single-photon detectors (7, 7', 7", 7‴), tagging means (8) connected to the single-photon detectors (7, 7', 7", 7‴) and rotating means (9) connected to the half-wave (4, 4') and quarter-wave plates (5, 5'). These elements are arranged and configured in such a way that the polarization of each photon comprised in the incoming light beam or initial sequence (2) of photons can be corrected before decoding. A system for transmitting a cryptographic key according to a Quantum Key Distribution, protocol with polarization correction and a method for correcting the polarization of each photon comprised in the sequence of photons used in the transmission of a cryptographic key according to a QKD protocol are also disclosed.

The present invention refers to benzothiazolium salts of formula (I) and its use in therapy. More particularly, they are useful in the treatment and/or prevention of parasitic infections. The present invention also relates to pharmaceutical composition comprising them.

The present invention refers to AG5 compound, and compositions or combined preparations comprising said compound, for use in the treatment and/or prevention of a fatty liver disease or disorder.

The vast majority of prokaryotic microorganisms remains uncultured and are not abundant enough to be effectively studied using metagenomic sequencing methods. Here, we present a novel PCR-free target capture sequencing approach that enables targeting specific genes or functions with full phylogenetic coverage in a single sequencing experiment, proving also a higher sensitivity and precision than regular shotgun and amplicon-based approaches.

The present invention provides a stimulation and recording neural probe (100) at least comprising: a substrate (10); a stimulation and recording array (12), said stimulation and recording array (12) including at least one single-layer or double-layer solution-gated graphene field effect transistor (SG-GFET) (14) for recording brain signals of a patient, and at least one electrode (16) for applying electrical stimulation to a brain tissue and/or recording brain signals of the patient; and metal tracks (18, 20) for the at least one electrode (16) and the at least one single-layer or double layer SG-GFET (14), encapsulated in respective first and second encapsulation layers (22, 24). The invention further provides a method of manufacturing a stimulation and recording neural probe, such as the neural probe described above. Still further, the invention provides closed-loop system (200) for brain stimulation and recording comprising a control unit (202) and a stimulation unit (204), the stimulation unit (204) comprising at least one neural probe as described above.

The present invention refers to a combination of enzymes that presents antimicrobial features. Specifically, the combination of the invention comprises an endolysin and a glucose oxidase. Surprisingly, the combination of the invention presents a synergistic antimicrobial effect that is useful for the control of food borne pathogens, such as Listeria monocytogenes.

The present invention relates to a genetic construct that allows overexpression in plants of the Arabidopsis HOP3 protein (AtHOP3) under the specific Arabidopsis BIP3 promoter (AtBIP3 promoter or pAtBIP3) under high salt conditions. The present invention also relates to transgenic plants, or parts thereof, comprising the genetic construct of the present invention, and to the use of these plants in crops subjected to environmental stress or any other condition that courses with ER stress.

The invention refers to a gripper for the separation of layers of a deformable material, the layers being stacked on a surface, comprising a foot (10) configured to be fastened to a robot, two arms for the grabbing of the layers and a motor (20) for the movement of the arms, wherein a first arm comprises a shaft (3) where a plurality of rolls (1, 2) is located, and a second arm comprises at least one finger (4) which further comprises a tip (6) with a longitudinal configuration, a housing (5), where one end of the tip (6) is fixed, and a spring (14), located within the housing (5) that provides longitudinal movement to the tip (6), wherein, one of the rolls (1, 2) comprises protuberances (13) on the surface to provide a friction surface, and the second arm is configured to move towards the first arm.

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