Consejo Superior de Investigaciones Científicas

The present invention refers to a method and/or to a system configured to measure and/or verify the radiation dose received by a patient after particle therapy treatment.

The present invention provides a catecholamine-based membrane for use in the treatment of cancer, wherein the self-standing catecholamine-based membrane is obtainable by a process comprising the steps of: (a) cross-linking a catechol derivative with an amine selected from the group consisting of: a known aliphatic amine hydrocarbon of formula (II); and an aromatic amine of formula (IIbis), in a liquid medium, wherein both the catechol and the amine are soluble, at a pH comprised from 6.5 to 10, and under appropriate agitation to create a catecholamine membrane in the air/liquid interface in the absence of any support; and b) isolating the membrane resulting from step (a) from the air/liquid interface. <img class="EMIRef" id="92cf978d-a85c-4e3c-981c-8d480bec373c-ia01" />

The present invention relates to new tricyclic organic compounds of formula (I):having antiviral activity, stereoisomers and pharmaceutically acceptable salts thereof, their use as a medicament, especially an antiviral medicament, and a pharmaceutical composition comprising the same.

A single-channel apparatus (100) implementing a method for reducing noise in spectral estimations comprises an input signal port (111) for receiving an input signal (10) that contains both direct and reflected components. A calibration switch (112) alternates the signal path between a calibration load (118), which isolates the system for measuring internal noise, and the input signal (10) for signal acquisition. These signals are processed through a single receiver chain (119) into a digital signal processor (120) which implements noise-reduction by processing the calibration and signal acquisition measurements to compute the respective autocorrelation functions, their Fourier transforms and estimations of the power spectral densities, to compute a cleaned autocorrelation function, and deliver an output (330) as spectral estimations with reduced noise. This apparatus is configured to achieve accurate spectral analysis by leveraging self-calibration, simplifying design and improving sensitivity in different applications. For example, the DSP (120) can perform a reflectometry-specific process which uses the cleaned autocorrelation function to estimate a reflection coefficient.

The invention relates to a reversible light-regulated agonists compounds of formula (I), or a pharmaceutical salt thereof, wherein the meanings for the various substituents are as disclosed in the description. Further, the invention relates to its use as a medicament, particularly for the treatment of skin diseases, autoimmune diseases, cancer, disorders of calcium metabolism, neuromuscular disorders, and cardiovascular diseases by local and temporarily restricted activation of Vitamin D receptor. <img class="EMIRef" id="0901e7dd-0530-4cd0-a74e-eb3c9b175eda-ia01" />

Method for producing a metadata chip (8) of data modules (41), comprising the steps of preparing a sacrificial layer (2), a first structural layer (3) configured to allows light to pass through, a design layer (4) being capable of including bidimensional metadata information, having a high optical contrast, shaping the design layer (4) using a photolithography, engraving or etching technique, to define shape and dimensions of a data module (41), shaping a first cover (31) of the data modules (41), and removing the sacrificial layer (2) in order to produce metadata chips (8) not easily visible, containing metadata security information, for enhancing security.

Present invention refers to a triboelectric nanogenerator and manufacturing method thereof, comprising: an electrode having a composite material layer attached to the electrode; and a counter-electrode having a tribo-negative material layer attached to the counter-electrode, configured to contact the composite material layer by an external force; wherein the composite material layer comprises a tridimensional nanostructure of a first tribo-positive isolating material having a plurality of interconnected pores filled with a second tribo-positive isolating polymeric material.

The present invention refers to a cementitious composite characterized in that it exhibits thermoelectricity and radiative cooling properties, such that the Seebeck coefficient is >2000 µV/K and the solar reflectance is above 0.95, both values included, particularly, the cementitious composite comprises zeolite selected among Z4A, ZSM.5, MCM-21, MCM-22 and mixtures of them, preferably in a high proportion over 60% by weight.

The present invention relates to a peptide-bound boron cluster complex for use in boron neutron capture therapy (BNCT). The present invention covers a library of complexes where one or more icosahedral boron clusters, such as carboranes and metallacarboranes, are linked to peptides or hormone analogues that bind to receptors or antigens overexpressed in tumors.

The invention discloses a polypeptide with hyaluronidase activity from Purpureocillium sp, comprising the amino acid sequence in SEQ. ID. No. 1 or a variant thereof, a polynucleotide comprising said polypeptide, a recombinant vector, a host cell and a method to produce the polypeptide of SEQ. ID. No. 1 or a variant thereof and its use to produce a mixture of hyaluronan oligosaccharides.