Sanofi

The present invention relates to combinations, pharmaceutical compositions and fusion molecules comprising an FGF21 (fibroblast growth factor 21) compound and a GLP-1R (glucagon-like peptide-1 receptor) agonist with optimized GLP-1R agonist / FGF21 compound activity ratio. It further relates to their use as medicaments, in particular for the treatment of obesity, being overweight, metabolic syndrome, diabetes mellitus, diabetic retinopathy, hyperglycemia, dyslipidemia, Non-Alcoholic SteatoHepatitis (NASH) and/or atherosclerosis.

A system for a drug delivery device (1) is provided, comprising: a housing (10, 350), a cartridge unit (300), which is attachable to the housing or releasably attached to the housing, wherein the cartridge unit comprises a cartridge unit guide feature (327), the cartridge unit guide feature being provided to establish a guiding interface (327, 351) with the housing in order to guide relative movement of the cartridge unit and the housing with respect to one another when attaching the cartridge unit to the housing, and wherein the cartridge unit comprises a cartridge unit interface feature (329, 334), the cartridge unit interface feature being provided to form a further interface, in addition to the guiding interface, with the housing the further interface being established when the cartridge unit is attached to the housing, wherein the guiding interface is a bayonet-type interface which defines at least two different stages of movement between the cartridge unit and the housing when the cartridge unit is attached to the housing, a first stage (351a) with at least axial movement by a first stage axial distance in a first stage axial direction and a second stage (351b) with at least rotational movement by a second stage angle in a second stage rotational direction, and wherein the further interface is or comprises a ramp interface.

The present disclosure relates to a bolus calculator (4.1) for determining a bolus (B) of insulin, the bolus calculator (4.1) having an input configured to be fed with a time series (h(t-τ)) of blood glucose values and to store at least one known pulse response (x(τ)) representing an active profile of at least one insulin, wherein the bolus calculator (4.1) is configured to convolute the time series (h(t-τ)) of blood glucose values with the known pulse response (x(τ)) to obtain the bolus (B) and to a method for calculating a bolus (B) of insulin, comprising feeding a time series (h(t-τ)) of blood glucose values into an input of a bolus calculator (4.1) and storing at least one known pulse response (x(τ)) representing an active profile of at least one insulin in the bolus calculator (4.1), convoluting the time series (h(t-τ)) of blood glucose values with the known pulse response (x(τ)) to obtain the bolus (B).

Methods, systems and apparatus are described for estimating titer of immunoglobulin single variable domains (ISVDs). The method includes: receiving an ISVD sequence dataset comprising data representative of at least one ISVD sequence; processing the received ISVD sequence dataset with a protein large language model configured for generating an ISVD embeddings dataset; processing the ISVD embeddings dataset with a ML model configured for generating an estimated ISVD titer value for each ISVD sequence of the ISVD sequence dataset based on the ISVD embeddings dataset input; and outputting data representative of the ISVD titer values corresponding to the ISVD sequence dataset for downstream processing.

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