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A blood processing device includes a pump system configured to be actuated during a blood processing procedure to draw blood from a subject and/or to convey a fluid to the subject. The blood processing device also includes a controller programmed to control operation of the pump system during the blood processing procedure. The controller is further programmed to retrieve or be provided with information regarding a medical profile of the subject, adjust at least one parameter of the blood processing procedure based at least in part on the medical profile of the subject, and execute the blood processing procedure with the adjusted parameter.

System and method for identifying a malfunction in a peristaltic pump (110) which comprises a rotor (150) with at least one roller (140), the method comprising the steps: obtaining a first upstream pressure value at a first rotor position in which the roller is positioned away from the tubing (120); activating the peristaltic pump until the rotor reaches a second position in which the roller has completed at least one rotation; obtaining a second upstream pressure value when the rotor is in the second position; determining the pressure difference between the first and the second upstream values; and generating an alert if the determination indicates pump operation abnormality. Alternatively, the method may also identify pump malfunction by determining the pressure difference from downstream pressure values.

A sterile connection device includes first and second carriages, each defining a portion of a first dock and a portion of a second dock. A first blade is associated with the first dock, while a second blade is associated with the second dock. When a pair of tubes is received in only the first dock, the tubes are cut using the first blade, then joined, and then a single replacement blade is moved into association with the second dock, which moves the second blade into association with the first dock and removes the first blade from association with the first dock. When a pair of tubes is received in each dock, the tubes are cut using the first and second blades, then joined, and then two replacement blades are moved into association with the docks, which moves the first and second blades out of association with the docks.

Systems and methods are provided for determining and controlling the location of an interface between separated blood components within a centrifuge. An optical monitoring assembly is used to determine the position of the interface, with the current position being compared to a target position. An error signal, which is indicative of the distance between the two positions, is input into a proportional-integral-derivative control algorithm to generate a control signal. The control signal is used to modify the rate at which a separated blood component is removed from the centrifuge so as to move the interface toward the target position. Blood characteristics, blood source characteristics, and/or the rate at which blood is pumped into the centrifuge are monitored for any changes, with a change in one or more of these factors being used to modify the control algorithm.

Blood processing systems, devices, and methods including a durable hardware component, a disposable fluid flow circuit, and a controller configured to provide alerts and/or notifications. More particularly, blood processing systems and devices including a controller configured to monitor a blood processing procedure and to provide one or more notifications based on a monitored event during the blood processing procedure.

Systems and methods are provided for monitoring and dynamically adjusting the operation of a pneumatic pump. The pump is controlled to alternately apply an initial negative pressure and an initial positive pressure to a flexible diaphragm of a pump chamber to draw fluid into the chamber and then convey the fluid from the chamber. The initial pressures are selected to be the minimum negative pressure at which the chamber is expected to completely fill during application of negative pressure to the diaphragm for an inflow duration and the minimum positive pressure at which the chamber is expected to completely empty during application of positive pressure to the diaphragm for an outflow duration. If a complete fill and/or a complete empty is not achieved, then the appropriate initial pressure is increased in order to arrive at the minimum pressures at which a complete fill and empty are actually achieved.

Systems and method for separating, collecting, treating target cells and infusing the treated target cells to a patient are disclosed. The closed system includes a predefined fluid pathway providing flow communication between a whole blood source and said patient.

A fluid separation device includes a centrifugal separator configured to receive a centrifugal separation chamber of a disposable fluid flow circuit, a pump system configured to convey a fluid into the centrifugal separation chamber and to remove a separated fluid component from the centrifugal separation chamber via an outlet, a color-based interface monitoring system configured to determine an interface position between separated fluid components continuously flowing through the centrifugal separation chamber based on dominant wavelength measurements of layers of separated fluid components during a centrifugal separation procedure, and a controller configured to measure the dominant wavelengths of the layers, calculate a duration as a color time for each measured dominant wavelength, set target color times, calculate error signals and calculate control signals to adjust the pump system to control the flow rate and interface position.

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