Universitat Autònoma de Barcelona

System and computer-implemented method of detecting fake multimodal media. In the method (100), the original image (2) of a multimodal post (1) is represented with a set of original visual features (4) while the original caption text (3) is converted into an original entity relationship graph (5). The original image (2) is used through reverse search (108) to find evidence text (8), and the original caption text (3) is used through direct search (110) to find evidence image (9). The nodes and edges of the entity relationship graph (18) of evidence text (8) and the visual features (13) of evidence image (9) are matched against the original entity relationship graph (5) and the original visual features (4) to find supporting and conflicting evidence. The result of the matching is also used in a feedback-based image retrieval (112) to refine the retrieval of an updated evidence image (9'). Finally, an interpretable decision on the authenticity of the multimodal post (1) in terms of matched nodes, edges and visual features is obtained.

The present disclosure relates to an in vitro method for diagnosing Alzheimer's disease (AD) in a subject, the method comprising a step of determining the level of β-secretase 1 protein (BACE-1) comprised in a population of brain-derived extracellular vesicles (BDEVs) in an isolated sample obtained from the subject, particularly wherein the population of BDEVs carry neuroligin-3 (NLGN3), wherein when the level of BACE-1 is equal to or higher than a reference this is indicative of a positive diagnosis of Alzheimer's disease. Also provided herein are methods of determining the classification of a subject according to the A/T/N system, methods for recommending a medical regimen, methods for determining therapeutic efficacy of a medical regiment, as well as methods of treatment for AD and AD-associated pathologies in a subject. Finally, the present disclosure provides kits and devices comprising: a) means for capturing a population of brain-derived extracellular vesicles; b) means for detecting the presence and/or for determining the level of BACE-1 protein; and optionally, c) a solid support.

The present disclosure relates to computer-implemented methods (100) for generating a virtual model of a first section of bone tissue including cortical bone tissue. The method comprises (104) obtaining microstructural cortical parameters including an indication of a number of osteons (210) and of a cross-sectional area of the osteons, a number of lamellae (212) forming the osteons, an indication of locations of osteons in the section of bone tissue and of dominance of the osteons. The method further comprises generating a virtual model using a generative design algorithm comprising (1061) defining a geometric space, (1062) generating a cortical cloud of points, (1064) segmenting the geometric space into substantially circular regions, defining an outer surface of the osteons. The method further comprises (1065) forming consecutive substantially concentric surfaces corresponding to the lamellae until the obtained virtual model satisfies boundary conditions formed by the microstructural cortical parameters.

Zusammenfassung wird geladen …

Zusammenfassung wird geladen …

Zusammenfassung wird geladen …

Zusammenfassung wird geladen …

Zusammenfassung wird geladen …

The invention relates to a method for the transduction of target cells, as well as to products for improving the transduction yield.

Zusammenfassung wird geladen …