VITO

The invention relates to an improvement on the removal of the Fmoc N-terminal protecting group in the synthesis of peptides; in particular in the synthesis of peptides using Solid Phase Peptide Synthesis (SPPS) or using discriminating membrane technology to separate out byproducts and excess reagents from the reaction mixture; more in particular in the synthesis of peptides using discriminating membrane technology to separate out byproducts and excess reagents from the reaction mixture.

The method involves recovering Bisphenol A (BPA) monomer from a thermoset BPA-epoxy resin through alcoholysis using a C1-C3 alcohol and a hydroxide as a reaction promoter. This process is conducted under an inert atmosphere at a pressure of at least 10 bar and a temperature between 200-225°C for a minimum of 5 hours. The method allows for high yields of BPA monomer with reduced reaction times and less base usage compared to existing methods. The process includes loading 2-10 wt.% of the resin in the alcohol and can involve further steps such as crystallization and recrystallization for purification.

The method involves identifying tumor-specific antigens in non-small cell lung cancer (NSCLC) by obtaining tumor and non-tumor tissue samples from patients and performing RNA sequencing to identify genomic variants. Patient-specific databases are generated, and mass spectrometry-based immunopeptidomics is used to detect MHC class I-bound and MHC class II-bound variant peptides in tumor tissue samples. A subset of these peptides, exclusive to tumor samples, is identified and confirmed for strong association with patient-specific MHC molecules using MHC allotype predictions. This subset is recognized as tumor-specific antigens in NSCLC.

The present invention is related to a process for reduction of carbon oxides and to materials and devices for performing the said process. In particular, the present invention is related etched electrochemically active particles and a method of production thereof, an electrode comprising the etched electrochemically active particles, a method of production of the electrode, a flow cell electrolyzer including the electrode and the process for reduction of carbon oxides using the flow cell electrolyzer.

The present invention is related to the field of membrane electrode assembly manufacture. It provides a method for true zero-gap membrane electrode assembly, comprising casting an electrode slurry onto an electrode separator slurry or an electrode separator to form a combination (100), followed by a phase inversion step that induces the formation of the membrane electrode assembly in situ (102). The electrode separator can be a polymeric, polymer-inorganic composite, cation exchange, anion exchange, bipolar or amphoteric membrane. The electrode slurry may include an anode or cathode slurry, and can contain a catalyst, binder, or conductive material. The phase inversion step involves exposing the combination to a non-solvent, such as water or alcohols, at temperatures ranging from about -10 °C to about 100 °C.

The present invention relates to a method for producing a carbonatable binder composition comprising a mixed Ca-Mg silicate, comprising heating a reactive mixture to a temperature between 800 °C and 1400 °C. The reactive mixture comprises between 40 and 90 % by weight of a mineral source material comprising a Mg-comprising silicate, and between 60 and 10 % by weight of a Ca-comprising compound, wherein the percentage by weight of each component of the reactive mixture is based on the total weight of the reactive mixture, wherein the molar ratio of elemental Mg to elemental Si in the mineral source material is between 5:1 and 1:5, wherein the Ca-comprising compound is capable of reacting with the Mg-comprising silicate, and wherein the mineral source material comprises equal to or lower than 10 % by weight of Al, based on the total weight of the mineral source material, wherein the amount of AI is expressed as AI oxide in the mineral source material. The invention further relates to a carbonatable binder composition comprising at least 15 % by weight of akermanite.

The present disclosure relates to a system and computer-implemented method for thermal characterization of buildings to assist in thermal assessment and/or control. A novel approach combining black-box and grey-box modeling techniques is integrated. Initially, a black-box fit is employed to generate model parameters based on training data specific to a building. These parameters are then used to establish initial parameters for a grey-box model through a parameter mapping process, which translates black-box model parameters into an equivalent set of grey-box model parameters while employing predefined equations and constraints to align the grey-box model with outcomes from the black-box model. The grey-box model parameters are further refined iteratively by fitting them against observed data using optimization techniques. This refinement aims to minimize discrepancies between model predictions and actual observations, with constraints imposed on the black-box model parameters to restrict the solution space during modeling.

A method for depolymerizing rigid polymeric polyurethane (PUR) or polyisocyanurate (PIR) foams involves grinding the foams to form a powder, adding the powder to liquid aliphatic amines to obtain a reaction mixture, and performing an aminolysis reaction on the reaction mixture under an inert atmosphere at elevated temperatures and extended incubation times. The process allows for the recovery of polymeric methylene diphenyl diisocyanate (PMDA) in high purity and high yields from the depolymerized foams. The method also includes recovering PMDA by precipitation and using it as a precursor to obtain polymeric methylene diisocyanate (PMDI) for the synthesis of PUR and PIR foams.

The present invention generally relates to the field of metal catalyzed depolymerization, and in particular provides a method for reductive depolymerization of polymer compositions containing polycarbonate in the presence of a heterogeneous metal catalyst. The present invention also provides a heterogeneous nickel catalyst suitable for reductive depolymerization of polymers, a method to prepare the catalyst, as well as use of the catalyst in reductive depolymerization methods.

A method and system for identifying parameters of an electrochemical model for characterization and/or operational management of batteries. Battery performance data is collected under various conditions, applying an electrochemical model to simulate battery chemistry and degradation. The model parameters are segmented into subsets related to specific conditions and aging effects. An optimization framework then estimates each subset of parameters by resolving individual optimization problems based on the performance data. These estimated parameters are used to refine the electrochemical model, which is subsequently employed for further characterization and management of batteries.