Winger

A method for fabricating one or more airbridge structures and one or more 3D integration modules on a patterned metallization layer of a wafer comprising qubits or superconducting electronics, the method comprising: providing the wafer with the patterned metallization layer; depositing an integrated metallization layer, either before or after providing and patterning a first resist layer; forming one or more airbridge structures which are contacting the patterned metallization layer at openings in the first resist layer, wherein the one or more airbridge structures are made of a superconductive material at operating temperatures; and fabricating 3D integration modules by electroplating predefined regions of the integrated metallization layer.

An energy handling system for converting, storing or transmitting energy, comprising a heat exchange unit with a first inner compartment and a flexible container mounted therein, forming a hermetically sealed volume filled with a first substance. The flexible container is controllably filled with a flexible-container fluid. At least one further heat exchange unit is in fluidic connection with the flexible container and/or the hermetically sealed volume for circulating the flexible-container fluid and/or the first substance, allowing heat exchange between the flexible-container fluid and/or the first substance and a second substance.

The invention relates to a bicelle entity comprising a bicelle structure with a rim and first and second amphiphilic compounds, the first having a longer hydrophobic chain, and at least one extension configured to bind a DNA origami envelope or its extension. It further relates to a DNA origami envelope adapted for such binding and to a complex formed by their assembly. A kit comprising the bicelle entity and the DNA origami envelope is also provided. The invention additionally concerns a hybrid pore device incorporating the complex with a solid-state pore. Methods are disclosed for manufacturing the complex by assembling the bicelle entity and DNA origami envelope, and for producing the hybrid pore device by integrating the complex with the solid-state pore.

In a first aspect, the present invention relates to a gas diffusion electrode (15) for electrochemical gas conversion, comprising: i) a porous solid structure (20), comprising a network (30) formed of a plurality of interconnected electrically conductive wires, and a catalytic surface (32) for catalysing the electrochemical gas conversion, said catalytic surface (32) being a surface of the network (30) as such or of a catalyst (31) coating the network (30); and ii) an electrolyte (50) in the porous solid structure (20) and in contact with the catalytic surface (32); wherein-in operation-at least one side of the porous solid structure (20) is directly exposed to a gas flow comprising the gas to be converted (60), or indirectly exposed to said gas flow through a diffusion layer having a thickness of 10 µm or less, preferably 1 µm or less.

A method for screening entities with different characteristics for their effect on biological cells of a biological cellular material, comprising: laterally constraining said entities having different characteristics in different locations of said biological cellular material, thereby preventing mixing of said entities having different characteristics; applying a transfection activation field to said different locations to allow said entities to be delivered into said biological cells, thereby allowing said entities to have an effect on said biological cells; and detecting said effect.

A device for delivering charged entities into biological cells of a biological cellular material, comprising a microelectrode array for supporting the biological cellular material, the microelectrode array comprising individually addressable electrodes made of an electrically-conductive CMOS-compatible material having an oxide top layer, and the charged entities electrostatically coupled to the oxide top layer. The oxide top layer may be a native oxide top layer. The charged entities can be negatively charged entities electrostatically attached to positively charged carriers directly attached to the oxide top layer, or positively charged entities encapsulated in a negatively charged carrier electrostatically coupled to the native oxide top layer. The electrically-conductive CMOS-compatible material can be a metal, metal nitride, or metal oxide. Charged entities differing in their characteristics may be electrostatically coupled to distinct electrodes of the microelectrode.

A method for identifying biomarkers of a health condition, comprising: providing a first neuronal circuit with neuronal cells from a first individual organism on a multi-electrode array, applying stimuli to the circuit, obtaining electrophysiological recordings, deriving cell-level and/or circuit-level features from the recordings, associating derived features with presence or absence of the health condition, comparing associated data with reference data, and determining if reference features or derived features are biomarkers for the condition.

A microfluidic device (100) comprising: a monolithic semiconductor substrate (10) with thermal conductivity ks; one or more heaters (20) on its top surface, each with a heating element (21); a thermal insulation layer (40) between the heaters (20) and the substrate (10), with thermal conductivity ki at least 50 times smaller than ks; and one or more liquid cooling units (30) with cooling fins (31) on the substrate's bottom surface. Each fin (31) has an extremity (32) within 100 µm of a heating element (21). A cover (60) encloses the cooling units (30), forming cooling channels (61) and including inlet (62) and outlet (63) ports for liquid circulation.

A barbecue appliance comprising: a grilling and/or griddling section; a slow cooking chamber; a fire pit for, in use, simultaneously supplying heat to both the grilling and/or griddling section and the slow cooking chamber; wherein the slow cooking chamber is adjustable in position relative to the fire pit to control its temperature.

An energy handling system (100) comprises a DC motor/generator (210) for converting between DC electrical energy and mechanical energy, and a compressed air energy storage equipment (220) for converting between mechanical energy and compressed air using energy exchange units based on a flexible fluid container in a vessel. A controller (230) is configured for converting DC electrical energy into mechanical energy using the DC motor/generator and for converting the mechanical energy into compressed air using the compressed air energy storage equipment. The controller (230) is further configured for re-converting compressed air stored in the compressed air energy storage equipment back into mechanical energy using the DC motor/generator. The energy handling system (100) also includes a DC-AC converter for converting DC electrical energy into AC electrical energy, and is configured for providing DC electrical energy to the DC-AC converter (120) using the compressed air energy storage equipment and the DC motor/generator (210). The energy handling system (100) further comprises at least one DC electrical green energy source (110) connected to the DC motor/generator for driving it as a motor using DC electrical energy.