Altmann Stößel Dick Patentanwälte PartG mbB

The present invention relates to a method for assessing pancreatic cancer in a subject, said method comprising (a) determining the biomarkers Ceramide (d18:1;C24:0), Lysophosphatidylethanolamine (C18:0), Phosphatidylethanolamine (C18:0, C22:6), Sphingomyelin (d17:1; C16:0), and CA19.9 in a sample from said subject; (b) comparing the biomarkers determined in step (a) to at least one corresponding reference; and (c) assessing pancreatic cancer in said subject based on said comparing in step (b). The present invention further relates to a computer-implemented training method of training at least one trainable model for assessing pancreatic cancer, to an automated machine learning model, and to a system related thereto.

Es wird vorgeschlagen eine Reinigungsvorrichtung (110) zur Reinigung von Reinigungsgut (112). Die Reinigungsvorrichtung (110) umfasst mindestens eine Steuerung (114); mindestens eine Reinigungskammer (116) zur Aufnahme mindestens eines Reinigungskorbs (118); mindestens eine Beaufschlagungsvorrichtung (120) zum Beaufschlagen des in dem Reinigungskorb (118) angeordneten Reinigungsgut (112) mit mindestens einem Reinigungsfluid (122) in der Reinigungskammer (116); und mindestens eine Transportvorrichtung (124) zum automatischen Transport des mindestens einen Reinigungskorbs (118) von einem Einlauf (126) der Reinigungskammer (116) durch die Reinigungskammer (116) hindurch zu einem Auslauf (128) der Reinigungskammer (116). Die Transportvorrichtung (124) umfasst mindestens einen Korbmitnehmer (130) eingerichtet zur Ausführung einer Oszillationsbewegung umfassend eine Vorwärtsbewegung (132) in Richtung einer Transportrichtung (134) der Transportvorrichtung (124) bei der der Korbmitnehmer (130) den Reinigungskorb (118) in die Transportrichtung (124) vorantreibt und eine Rückwärtsbewegung (136) an dem Reinigungskorb (118) vorbei entgegen der Transportrichtung (134) der Transportvorrichtung (124); mindestens einen von der Steuerung (114) gesteuerten Antrieb (138) zum Antreiben der Oszillationsbewegung des mindestens einen Korbmitnehmers (130), umfassend einen Motor (140) und einen Frequenzumrichter (142), wobei die durch den Frequenzumrichter (142) bereitgestellte Antriebsfrequenz für den Motor (140) derart variiert, dass die Rückwärtsbewegung (136) des Korbmitnehmers (130) schneller ist als die Vorwärtsbewegung (132) des Korbmitnehmers (130).Weiterhin vorgeschlagen wird ein Verfahren zum automatischen Transport von mindestens einem Reinigungskorb (118) durch zumindest eine Reinigungsvorrichtung (110) sowie ein Computerprogramm zur Ausführung von zumindest einem Teil des Verfahrens und ein Computerlesbares Medium auf dem das Computerprogramm gespeichert ist

An organic electroluminescent device comprises a first electrode, a second electrode, and an organic layer disposed between the first electrode (104) and the second electrode (108), the organic layer (106) comprising at least one charge-neutral metal-organic coordination compound of general formula (1-1):with• M being Gd(III) or Ce(III),•independently representing each a singly electrically negatively charged ligand with• R₁ and R₃ being independently, preferably identical in each occurrence, selected from organyl groups having at least 6 atoms, and• R₂ and R₄ being independently, preferably identical in each occurrence, selected from the group consisting of hydrogen, deuterium, fluorine, nitrile, and an organyl group, and with• L representing a singly electrically negatively charged ligand, and• broken lines indicating coordinative and/or ionic bonds.

The present invention relates to optical coupling between optical components and, more particular, to an optical probe (1) configured for optical testing of at least one micro-optical component (50), to a method for producing an optical probe (1), and to a method for optical testing of at least one micro-optical component (50). The optical probe (1) is comprising:- a probe head (10), wherein the probe head (10) comprises a test component (2);- at least one micro-optical element (20), wherein the micro-optical element (20) is a separate element with regard to the test component (2) and in mechanical contact with the test component (2),wherein the micro-optical element (20) is configured to optically couple at least one light beam (3) between the test component (2) and the micro-optical component (50), thereby being configured to determine an emission characteristics of a coupling location (52) comprised by the micro-optical component (50) , wherein the micro-optical component (50) further comprises a beam-shaping element (51a), wherein the beam-shaping element (51a) is arranged in a manner that at least a portion of the light beam (3) is travelling through the beam-shaping element (51a).

An organic electroluminescent device comprises a first electrode, a second electrode, and an organic layer disposed between the first electrode and the second electrode, the organic layer comprising at least one charge-neutral metal-organic coordination compound, with the metal-organic coordination compound comprising at least one electrically negatively charged gallium compound of general formula (1-1): <img class="EMIRef" id="1da0d0c8-8e13-4782-87a6-f3dc7487ecae-ia01" /> with A, and B independently being substituted or non-substituted heterocyclic rings, and broken lines indicating e.g. a chemical bond or linking group at any available position.

A tissue sample that has been removed from a subject can be evaluated. A transporter system for carrying a tissue sample includes a transport container, a fixative in the transport container, and a cooling device that reduces and/or maintains the temperature of the fixative to perform a pre-soaking process. A portable transporter system adapted to carry a tissue sample contacting a fixative, can include: a transport container including: a holding chamber; and a fixative; and a container lid including: a cassette holder operable to be coupled to the standard histology cassette and including a first seal; and a cassette receiver operable to be releasably coupled to said transport container and including a second seal, where the cassette holder and cassette receiver are operable to be attachably coupled to one another upon insertion of a standard histology cassette coupled to the cassette holder into the cassette receiver.

The present invention relates to an alcohol conversion process wherein a base together with a homogenous transition metal catalyst are employed. In the process, preferably bio-based alcohols such bio-ethanol are employed which contain trace components of other alcohols.

The present invention relates to a process for producing an acid, and in particular to an alcohol conversion process employing a homogeneous catalyst and a base, wherein an ester as a byproduct of said alcohol conversion process is formed, and wherein an acid from the ester is obtained.

A spectrometer (110) and a method for skin-layer specific spectroscopy are disclosed. The spectrometer (110) comprises - at least one illumination source (112) configured for illuminating a sample (114) of a subject with at least one illumination light (116) beam having at least one wavelength in an optical spectral range, wherein the illumination source (112) is configured for transmitting the illumination light beam (116) to the sample (114) along a direction of propagation (120); - at least one detector (124) sensitive to light in the optical spectral range, wherein the detector (124) is configured for detecting light impinging on the detector (124) under at least one direction of collection (126); wherein the illumination source (112) and the detector (124) are separated by a baseline (130), wherein the direction of collection (126) and the direction of propagation (120) of the illumination light beam (116) form an angle of inclination α with α ≠ 0.

The invention relates to a method for operating a computed tomography device (150), wherein the computed tomography device (150) comprises at least one x-ray radiation source (131) configured for generating x-ray radiation cones (132) for irradiating an object (134), wherein the computed tomography device (150) comprises at least one detector (136) configured for detecting the x-ray radiation of the x-ray radiation cones (132) that have interacted with the object (134), wherein the x-ray radiation source (131) comprises at least one electron optic arrangement (138) configured for variably arranging at least one electron beam (140) onto a plurality of positions of focal spots on at least one target comprised by the x-ray radiation source (131) in a manner that a plurality of different x-ray radiation cones (132) emerging from the focal spots is generated in order to image different portions of the object (134); the method comprising:- performing a projection image scanning sequence (PSS) by using an imaging focal spot pattern in order to generate a plurality of projection images, wherein the imaging focal spot pattern comprises a plurality of x-ray focal spot positions on the at least one target (144) such that a volume of the object (134) to be reconstructed is irradiated by the different x-ray radiation cones (132);- performing a tomographic scanning sequence (TSS) by performing the projection image scanning sequence (PSS) at differing viewing angles;- performing an image reconstruction algorithm using the projection images in order to reconstruct a 3D-image of the object (134).The invention further relates to a computed tomography device (150), a computer program and a computer-readable storage medium. The invention may be employed in order to extend the field of view for a specific viewing angle.