Roche Diagnostics

Mass spectrometric method for determining a relative quantity of at least one analyte present in a first biological sample relative to the quantity of the same at least one analyte present in a second biological sample, the method comprising the steps of: providing the first biological sample comprising the at least one analyte labeled with a first isobaric mass tag; providing the second biological sample comprising the at least one analyte labeled with a second isobaric mass tag different from the first isobaric mass tag; mixing the first biological sample with the second biological sample to obtain a sample mixture; introducing, by direct inlet, a stream of the sample mixture into an ionization source; ionizing the stream of the sample mixture to generate labeled analyte ions of the at least one analyte labeled with the first and labeled with the second isobaric mass tag; separating the labeled analyte ions from other components of the sample mixture based on their ion mobility; fragmenting the separated labeled analyte ions to release reporter ions from the first and second isobaric mass tags; and measuring signal intensities of the reporter ions at their respective mass-to-charge ratios and determining therefrom the relative quantity of the at least one analyte present in the first biological sample relative to the second biological sample based on the measured signal intensities.

The invention relates to a laboratory sample distribution device (1), comprising: a base (2) having a transport surface (3), at least one drive-controllable lane belt (4) defining a transport lane (5), the lane belt (4) being cleated for form-fit engagement with a respective sample container carrier (50) to be moved over the transport surface (3) along the transport lane (5), at least one drive-controllable cross-track belt (6) defining a transport cross-track (7), the cross-track belt (6) being cleated for form-fit engagement with a respective sample container carrier (50) to be moved over the transport surface (3) along the transport cross-track (7), the transport cross-track (7) meeting the transport lane (5) at an angle (α), an operation mode in which the lane belt (4) and the cross-track belt (6) are controlled for transferring a respective sample container carrier (50) between the transport lane (5) and the transport cross-track (7), and another operation mode in which the lane belt (4) and the cross-track belt (6) are controlled for moving a respective sample container carrier (50) along the transport lane (5) past the transport cross-track (7).

The present disclosure concerns a method of sample identification of a sample in a sample processing system, comprising: registering, for each sample of a plurality of samples to be processed by the sample processing system, initial sample identification data uniquely identifying the respective sample among the plurality of samples; registering, for each sample of the plurality of samples, initial sample fingerprint data indicative of an internal state of the respective sample; associating, for each sample of the plurality of samples, the respective initial sample identification data with the respective initial sample fingerprint data; determining that a sample identification condition is met, wherein the sample identification condition is indicative of a need to identify a specific sample being processed by the sample processing system; measuring, for the specific sample, current sample fingerprint data indicative of a current internal state of the specific sample; and mapping the current sample fingerprint data to the initial sample fingerprint data of one sample of the plurality of samples in order to identify the specific sample. The present disclosure further concerns a corresponding sample processing system and non-transitory computer-readable storage medium.

The present invention relates to a clinical diagnostic system, a method for determining the presence or level of at least one analyte of interest in a biological sample, a kit and the uses thereof for efficiently and/or robust detection of an analyte of interest.

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