Simmons & Simmons LLP (Munich)

An injection molding machine (10) according to an embodiment includes: a first feeder (F1) configured to supply raw-material chips made of virgin material to a barrel (11); a second feeder (F2) configured to supply raw-material chips made of recycled material obtained by pulverizing metal scrap generated from the injection molding machine (10); and a controller (CNT) configured to control the first and second feeders. The controller (CNT) controls the first and second feeders so as to add the recycled material to the virgin material at a mass ratio within a predetermined range.

Die Erfindung stellt bereit einen Flaschenträger (1), ein Gebinde zur Aufnahme einer Vielzahl von Flaschen, und ein Tragsystem für Flaschen, umfassend einen Flaschenträger (1) und mindestens einen Flaschenkasten (10) oder Tray, wobei der Flaschenträger (1) aus einem einteiligen Zuschnitt (2) faltbaren Flachmaterials zum manschettenartigen Umwickeln um die Vielzahl von Flaschen besteht, und wobei der Flaschenträger in einem Übergangsbereich zwischen einer Deckenwand und jeweiligen Seitenwänden eine Vielzahl von Flaschenkopfaussparungen (8) zum jeweiligen Hindurchtreten eines Kopfabschnitts einer aufzunehmenden Flasche vorgesehen ist, und wobei ein Abstand (9) zwischen zwei Flaschenkopfaussparungen (8) so voreingestellt ist, dass die Flaschenbäuche bei einem Anheben des Flaschenträgers mittels der mindestens einen Eingriffsaussparung (7) nicht dauerhaft aneinander in Anlage gehen.

In one embodiment, a vertical mold clamping apparatus includes a fixed platen, a turntable placed on the fixed platen, and a plate which is provided between the fixed platen and the turntable and supports the turntable so as to be rotatable, and a lubricant is supplied from a lateral side of the plate to an upper surface of the plate that faces a lower surface of the turntable.

The present disclosure is to provide an injection molding machine and the like that allows the user to easily grasp interlock information related to cores. An injection molding machine (1), includes: an injection device (3) melting and injecting an injection material; a mold clamping device (4) clamping a metal mold (41) with a core (47) that is injected with the injection material; a control device (2) controlling an action of the core (47); and a display unit (24) displaying an action status of the core (47), and the display unit (24) includes a core action icon (71) indicative of an action of the core (47), and a first information icon (74) indicative of interlock information concerning the core (47), and the core action icon (71) and the first information icon (74) are displayed in association with each other.

Therapeutic combinations of immunoconjugates that bind to FOLR1 (e.g., IMGN853) with anti-VEGF agents (e.g., bevacizumab), a platinum-based agent, and/or doxorubicin are provided. Methods of administering the combinations to treat cancers, e.g., ovarian cancers, with greater clinical efficacy and/or decreased toxicity are also provided.

A vehicle (100) on which an autonomous driving kit (ADK) (200) is mountable comprises a control system (120) configured to control a plurality of functions of the vehicle (100) and a vehicle control interface box (VCIB) (110) configured to mediate communication of a signal between the ADK (200) and the control system (120). The ADK (200) is configured to operate in one control mode selected from a plurality of types of control modes. The VCIB (110) is configured to receive from the ADK (200) and store function setting information for each of the plurality of types of control modes. The function setting information is information indicating whether each of the plurality of functions is enabled or disabled. The VCIB (110) is configured to request the control system (120) to enable or disable each of the plurality of functions based on the function setting information corresponding to the selected one control mode.

The present disclosure relates to dosing regimens of pharmaceutical compositions of anti-CD40 antibodies, such as humanized anti-CD40 antibodies, and uses thereof in the treatment of rheumatoid arthritis.

An objective of the present invention is to provide stable antibody-containing formulations which are suitable for subcutaneous administration and in which aggregation formation is suppressed during long-term storage.The present inventors discovered that a significant stabilization effect was achieved by using an acidic amino acid, aspartic acid or glutamic acid as a counter ion species in histidine buffer or tris(hydroxymethyl)aminomethane, specifically by using histidine-aspartate buffer or histidine-glutamate buffer, or tris(hydroxymethyl)aminomethane-aspartate or tris(hydroxymethyl)aminomethane-glutamate as a buffer. The present inventors also discovered that a significant stabilization effect was achieved by using an acidic amino acid, aspartic acid or glutamic acid, as a counter ion species to a basic amino acid such as arginine, specifically by using arginine-aspartate or arginine-glutamate.

The present invention relates to method of producing a lipidated protein, a pharmaceutical composition comprising the protein of any of SEQ ID NOs: 1, 2, and/or 3 and/or the lipidated form of a protein comprising the protein of SEQ ID NO: 7 (C-TAB.GS) and/or SEQ ID NO: 8 (C-TAB.G5.1), especially the protein of SEQ ID NO: 12 (Lip-C-TAB.G5.1), and/or a lipidated form of a protein comprising the protein of SEQ ID NO: 15 (Spike protein of SARS-CoV-2) and/or a lipidated form of a protein comprising the any of the proteins of SEQ ID NOs: 16-22 (hMPV F protein), and the pharmaceutical composition for use as a medicament, particularly a vaccine and/or for use in a method for eliciting an immune response in a human against Lyme disease, a disease caused by Clostridium difficile or hMPV and/or of SARS-CoV-2 (COVID-19).

Die vorliegende Erfindung betrifft einen Transportbehälter (1) mit Behälterrahmen (2) und Behälterboden (3), wobei der Behälterrahmen (2) und der Behälterboden (3) einen Behälterinnenraum (4) festlegen, wobei der Behälterrahmen (2) Seitenwände (21, 22) des Transportbehälters (1) ausbildet, von denen mindestens zwei gegenüberliegende Seitenwände (21, 22) mit einem Tragegriff (5, 6) und mit einem daran angrenzenden Durchgriffsloch (7, 8) versehen sind, und wobei der Tragegriff (5, 6) zumindest an seiner zum Behälterinnenraum (4) weisenden Seitenfläche (5a; 6a) eine Vielzahl an Vertiefungen (51; 61) aufweist, die zumindest vier sechs- oder mehreckige Hohlräume (51a; 61a) umfasst, deren jeweilige Innenoberfläche zumindest teilweise eine Kugelsegmentform ausbildet. Ferner betrifft die vorliegende Erfindung ein entsprechendes Spritzgussverfahren sowie ein entsprechendes Spritzgusswerkzeug.