Fujifilm Patente

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A drug discovery support apparatus includes a processor, and the processor is configured to: acquire a first prediction value of a degree of inhibition indicating a degree to which a flow of ions in a plurality of ion channels present in an iPS myocardial cell, which is a myocardial cell derived from a human iPS cell, is inhibited by a candidate substance for a drug for each of the ion channels and for each added amount of the candidate substance, the first prediction value being output from a prediction model based on a first fluctuation waveform that is a fluctuation waveform of an extracellular potential of the iPS myocardial cell and is measured in a case where the candidate substance is added to the iPS myocardial cell while the added amount is changed; derive an index value indicating a dose-response relationship of the candidate substance for each of the ion channels, based on the first prediction value for each added amount; and present, to a user, estimated reference information that corresponds to the index value and is referred to in order to estimate a mechanism of action of the candidate substance.

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There is provided an ink jet ink for an impermeable base material, which can improve retort resistance of a laminate obtained by laminating a base material for lamination on an image of an image recorded material obtained by applying an ink jet ink onto an impermeable base material to record an image.

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Provided is a method for manufacturing a product, including a culture step of culturing cells in a culture solution accommodated in a tank, and a separation step of using a hollow fiber membrane filter which has a hollow fiber membrane having a primary flow passage extending in a longitudinal direction inside the hollow fiber membrane and has a housing accommodating a plurality of the hollow fiber membranes, the hollow fiber membrane filter having a secondary flow passage in a space of the housing outside each of the hollow fiber membranes, to feed the culture solution to the primary flow passage, and allowing a permeated liquid containing the product to permeate through the secondary flow passage to separate the cells and the product in the culture solution from each other, in which, in the separation step, in a case where a difference in pressure between both ends of the primary flow passage on a supply side and a discharge side during the feeding of the culture solution is denoted as ΔP [Pa], a membrane resistance of the hollow fiber membrane is denoted as r, and a flow passage resistance of the secondary flow passage is denoted as R, ΔP/2(r + R) during the feeding of the culture solution is 0.0005 mL/min or less.

Provided is a method for manufacturing a product, including a culture step of culturing cells in a culture solution accommodated in a tank having a capacity of 100 L or more, and a separation step of using a hollow fiber membrane filter which has a hollow fiber membrane having a primary flow passage extending in a longitudinal direction inside the hollow fiber membrane and has a housing accommodating a plurality of the hollow fiber membranes, the hollow fiber membrane filter having a secondary flow passage in a space of the housing outside each of the hollow fiber membranes, to feed the culture solution supplied from the tank to the primary flow passage, and allowing a permeated liquid containing the product to permeate through the secondary flow passage to separate the cells and the product in the culture solution from each other, in which, in the separation step, in a case where a difference in pressure between both ends of the primary flow passage on a supply side and a discharge side during the feeding of the culture solution is denoted as ΔP [Pa], and a viscosity of the culture solution is denoted as µ [Pa·s], ΔP/µ during the feeding of the culture solution is 4.9 × 10⁶ [1/s] or less.

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Provided are an endoscope system and an endoscope device in which a part to be observed can be easily grasped in endoscopy targeting a part having poor visibility. The endoscope system and the endoscope device include a processor that acquires shape data of an insertion part of an endoscope in a body cavity in an examination using the endoscope with movement of a distal end of the insertion part; and a memory that stores shape data, and the processor stores the shape data at a position of an object to be observed in a first examination as first shape data in the memory, and determines that the distal end of the insertion part has reached the position of the object to be observed and provides notification of a result of determination in a case where the shape data acquired in a second examination after the first examination matches the first shape data.

The ultrasonography apparatus includes at least one processor (100), in which the processor acquires, from a detector (14) that detects a posture of a palm of a subject in capturing an ultrasound image, information representing a posture of the palm at a first time point as a first detection result, acquires information representing a posture of the palm at a second time point, which is after the first time point and is a time point during capturing of the ultrasound image, as a second detection result, derives a difference between the posture of the palm at the first time point and the posture of the palm at the second time point based on the first detection result and the second detection result, and performs notification in a case in which the derived difference is equal to or greater than a threshold value.

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Provided are a composition for a positive electrode containing a positive electrode active material consisting of a large particle group A having a particle diameter of 5.0 µm or more and a small particle group B having a particle diameter of less than 5.0 µm, in which, in a number-based particle size distribution of the positive electrode active material, in a case where the total frequency is set to 100%, a frequency of the large particle group A is 60% or more and a frequency of the small particle group B is 40% or less, and a surface tension γB (mN/m) of the small particle group B with respect to N-methylpyrrolidone satisfies an expression B1: 15.0 ≤ γB ≤ 40.0; a positive electrode sheet including a positive electrode active material layer formed of the composition for a positive electrode; and a non-aqueous electrolytic solution secondary battery using the positive electrode sheet.

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Provided are a method for manufacturing a non-aqueous electrolytic solution secondary battery in which a positive electrode collector, a positive electrode active material layer, a separator, a negative electrode active material layer, and a negative electrode collector are laminated in this order, the method including applying a slurry for forming a positive electrode onto the positive electrode collector to form a slurry-like positive electrode active material layer, and adding a solvent having a vapor pressure of 4.0 kPa or more to the slurry-like positive electrode active material layer, the slurry for forming a positive electrode, containing a positive electrode active material at a content of 75% by mass or more, a conductive auxiliary agent, an electrolyte, and a non-aqueous solvent (I) in which a content of the solvent having a vapor pressure of 4.0 kPa or more is less than 1.0% by mass; and a non-aqueous electrolytic solution secondary battery which can be obtained by the manufacturing method.

An information processing apparatus includes a processor, in which the processor executes control of outputting a flowchart that indicates a procedure for obtaining a toxicity evaluation result for a plurality of target compounds and that includes a plurality of processing steps set in advance and arranged in time series and a determination processing step in which a determination condition is changeable and a subsequent path branches according to a determination result, and, in a case where, after the toxicity evaluation result is obtained according to the procedure for at least one target compound, the determination condition in the determination processing step is changed and the toxicity evaluation result is obtained under the changed determination condition, in the control of outputting the flowchart, in a case where a change occurs between an unchanged path taken to reach the toxicity evaluation result before the change in the determination condition and a changed path taken to reach the toxicity evaluation result after the change in the determination condition, the processor displays the path in which the change has occurred in a distinguishable manner.

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