Novo Nordisk

An apparatus (1) for stoppering a plurality of pharmaceutical cartridges (10), comprising: (a) a first support structure (130) for receiving a plunger nest (50) holding plunger stoppers (15) in a regular arrangement (D) forming a plurality of parallel rows of openings, (b) a second support structure (140) for receiving a cartridge nest accommodating a plurality of cartridges (10) with a filling opening upwards and disposed in the same regular arrangement (D), (c) a funnel arrangement (160) having a plurality of funnels (165) disposed in the same regular arrangement (D) for guiding a respective plunger stopper (15) for insertion into the filling opening (12) of a respective cartridge (10), (d) a vacuum manifold unit (150) having a plurality of openings (155a, 155b) disposed in the same regular arrangement (D), each opening (155a, 155b) accommodating a respective funnel (165), the vacuum manifold unit (150) being configured for distributing vacuum from a vacuum source to the plurality of openings (155a, 155b) and into the funnels (165), and (e) a pushing mechanism (110,112) configured for pushing the plunger stoppers (15) from the plunger nest (50) through the funnels (165) and into the filling opening (12) of the cartridges (10).

A medical component container (200) comprising: a) a container body (100) having a base (102), a peripheral wall (107) having a lower end that is contiguous to a perimeter of the base (102) and extending upward towards peripheral edges surrounding and opening, and a reinforcing frame (106) that surrounds the opening, b) a protective film (150) that is attached to the peripheral edges for sealing the opening, amd c) two or more vertically stacked trays (10) each holding a plurality of medical components (1) in a regular arrangement, the lowermost tray (10) being supported on or at the base (102), wherein the peripheral wall (107) is configured for collapsing so that, after the protecting film (150) has been removed from the peripheral edges, and upon an external force acting to move the base (102) vertically upwards, the stacked trays (10) are lifted by the base (102) to emerge upwards from the plurality of peripheral edges. Also disclosed is a medical component container (200) having a protecting film (150) removable by an automatic gripper.

Disclosed herein are an aqueous pharmaceutical formulation comprising cagrilintide and an aqueous formulation comprising semaglutide. The compositions of these two pharmaceutical formulations allow for their presentation in, and administration using, the dual-chamber medical device disclosed herein. Individuals with diseases, such as diabetes and/or obesity and/or related co-morbidities, may benefit from the co-administration of semaglutide and cagrilintide, and/or of the two liquid pharmaceutical formulations disclosed herein, using the medical device disclosed herein.

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