Pacesetter

Embodiments are disclosed of an assembly (216, 300, 400, 500, 600, 700, 750) adapted to be attached to a biostimulator (100). The assembly (216, 300, 400, 500, 600, 700, 750) includes a flange (218, 302, 402, 502, 602, 702) adapted to be attached to a distal end of the biostimulator (100). The flange (218, 302, 402, 502, 602, 702) includes a base (308, 408, 508, 608, 708) adapted to be attached to the distal end of the biostimulator (100), and a hub (310, 410, 510, 610, 710) positioned on the base (308, 408, 508, 608, 708). The hub (310, 410, 510, 610, 710) has a proximal end (311), a distal end, an interior surface (312, 412, 512, 612, 712), and an exterior surface (314, 414, 514, 614, 714). The proximal end (311) of the hub (310, 410, 510, 610, 710) is attached to the base (308, 408, 508, 608, 708), and the exterior surface (314, 414, 514, 614, 714) includes a first attachment mechanism (316, 416, 516, 616, 716). A fixation mount (220, 304, 404, 504, 604, 704) is adapted to be attached to the flange (218, 302, 402, 502, 602, 702). The fixation mount (220, 304, 404, 504, 604, 704) includes a second attachment mechanism (324, 434, 534, 624, 726) to engage with the first attachment mechanism (316, 416, 516, 616, 716). An assembly lock (417, 625, 722) engages the first attachment mechanism (316, 416, 516, 616, 716) and the second attachment mechanism (324, 434, 534, 624, 726) to fasten the flange (218, 302, 402, 502, 602, 702) to the fixation mount (220, 304, 404, 504, 604, 704).

A biostimulator transport system (300) includes a locking tube (402) having a central lumen. The biostimulator transport system (300) includes a tether (602) extending through the central lumen. The tether (602) includes a locking end (604) coupled to a tether body (606). The locking end (604) is wider than the tether body (606). Other embodiments are also described and claimed.

A loading tool (904) for loading a biostimulator (100) onto a biostimulator transport system (300) is described. The loading tool (904) includes a body portion (906) having a biostimulator volume (1016) to receive the biostimulator (100), and a receptacle portion (908) extending from the body portion (906). The receptacle portion (908) has a receptacle wall (912) extending around a receptacle volume (910) to receive the biostimulator transport system (300). The receptacle volume (910) is in fluid communication with the biostimulator volume (1016). A loading slot (914) extends laterally through the receptacle wall (912) into the receptacle volume (910). Other embodiments are also described and claimed.

An implantable medical device (IMD) (100) includes a housing (02), a tip electrode (104), a plurality of fixation tines (106), and a deployment mechanism (108, 300, 300a, 450, 500). The housing (102) includes a distal tip (110). The distal tip (110) has a distal face (112). The tip electrode (104) is mounted to the distal tip (110) of the housing (102) and is exposed along the distal face (112). The fixation tines (106) are mounted to the distal tip (110) of the housing (102). The fixation tines (106) include hook features (120) for securing to tissue of the patient. The deployment mechanism (108, 300, 300a, 450, 500) is able to deploy the fixation tines (106) to a deployed state. The fixation tines (106) in the deployed state are exposed along the distal face (112), and can embed into the tissue of the patient to secure the IMD (100) at a target implant location.

An electrocardiogram (ECG) system (100) includes a computing device (102) configured to be communicatively connected to patch electrodes (104) that are affixed to skin of a patient. The computing device (102) includes one or more processors (118) configured to obtain electrical signals sensed by the patch electrodes (104) while the patch electrodes (104) are located at actual electrode locations. The processor(s) (118) are configured to generate initial ECG data based on the electrical signals according to assumed electrode locations on the patient that differ from the actual electrode locations. The processor(s) (118) are configured to convert the initial ECG data to converted ECG data by determining a relationship between the assumed electrode locations and the actual electrode locations; determining voltage values for reference vectors based on the initial ECG data and the relationship; and multiplying the voltage values for the reference vectors by a set of predetermined coefficients.

Leadless pacemakers (LPs) and systems for use therewith are disclosed. During a first period of time, during which an LP (102a, 102b) receives event messages from a second LP (102b, 102a), the LP (102a, 102b) times its pacing of a first cardiac chamber based on the event messages received from the second LP (102b, 102a) so that AV synchrony is maintained, and the LP (102a, 102b) determines and stores count value(s). Based on at least one of the count value(s), the LP (102a, 102b) determines a compensation offset indicative of a drift between timing circuitry (160) of the LP (102a, 102b) and timing circuitry (160) of the second LP (102b, 102a). During a second period of time, during which the LP (102a, 102b) does not receive event messages from the second LP (102b, 102a), the LP (102a, 102b) times its pacing of the first cardiac chamber based on the compensation offset to thereby compensate for the drift so that the AV synchrony is also maintained during the second period of time.

A biostimulator (100) includes a housing (302) having a longitudinal axis (304) and containing an electronics compartment (306). The biostimulator (100) includes a fixation element mount (307) mounted on the housing (302). The biostimulator (100) includes a fixation element (106) mounted on the fixation element mount (307). The fixation element (106) includes a helical wire (320) extending helically about the longitudinal axis (304). The helical wire (304) tapers inward from a proximal turn (402) to a distal tip (322).

A biostimulator (100) includes a housing (302) having a longitudinal axis (304) and containing an electronics compartment (306). A fixation element mount (311) is mounted on the housing (302) and a fixation element (106) is mounted on the fixation element mount (311). The fixation element (106) extends helically about the longitudinal axis (304) and has an outer dimension (902). The outer dimension (902) increases in a distal direction (408) over a proximal section (904) of the fixation element (106), and the outer dimension (902) decreases in the distal direction (408) over a distal section (906) of the fixation element (106).

A biostimulator transport system (300) includes a catheter shaft (402) having a catheter lumen (502) extending longitudinally to a distal catheter end (404). The biostimulator transport system (300) includes a docking cap (320) coupled to the catheter shaft (402) and having a docking cavity (512). A drive shaft (503) extends through the catheter lumen (502) to a distal shaft end (504). The biostimulator transport system (300) includes a motion converter (506) coupling the drive shaft (503) to the docking cap (320). The motion converter (506) converts longitudinal motion of the drive shaft (503) into rotational motion of the docking cap (320).

Disclosed herein is an implantable medical device (IMD) (100), and system (5) for denoising biological signals. The IMD (100) generates a biological signal representative of a physiologic parameter of a patient (3) and normally analyzes the biological signal to detect a characteristic of interest (COI) indicative of a pathophysiologic condition of the patient (3). The present technology denoises, when the IMD (100) is exposed to a noise causing condition, noisy biological signal segments of the biological signal generated while the IMD (100) is exposed to the noise causing condition using a denoising prediction model (400) to obtain denoised biological signal segments. The denoising prediction model (400) is trained to predict a denoised biological signal segment from a noisy biological signal segment. The denoised biological signal segments can then be analyzed to detect the COI indicative of the pathophysiologic condition of the patient (3).