BIRD & BIRD SOCIETA TRA AVVOCATI S.R.L.

A process is described for the production of high-purity melamine from the pyrolysis of urea, with optimization of the deammoniation step of the mother liquors.

The innovative catheter-based system comprises a catheter (1000) able to map, ablate, and/or to deliver at least a therapeutic agent into at least a target area of a cardiac tissue, the catheter (1000) includes a therapeutic ablator device (100) disposed in a distal portion of the catheter (1000), the therapeutic ablator device (100) comprises: a drug delivery portal (110), able to drug locally released; a plurality of railings (120) arranged symmetrically and parallel to the drug delivery portal (110). The innovative method (2000) of use of the catheter-based system.

The present invention relates to a process for the synthesis of melamine by the pyrolysis of urea, with an optimized dissolution and ammonolysis step. In particular a stream of a post-reactor section is fed to a dissolution step in aqueous ammonia solution, wherein the quantity of ammonia in the aqueous ammonia solution varies within the range of 15 to 28% by weight with respect to the total weight of the aqueous ammonia solution, in a dissolver (MD) at a temperature within the range of 160 to 180°C and at a pressure higher than 25 barg,

A gas meter (100) configured to be installed at a site. The gas meter comprises: - an inlet duct (102(in)) couplable to a gas distribution network for receiving gas; - a measuring chamber (110) in fluid communication with said inlet duct (102(in)) and with an outlet duct (102(out)), said outlet duct (102(out)) being coupled to a user network for distributing gas at said site; - a gas metering system (115, 120, 130) configured to generate measurements indicating gas delivery from the distribution network to said user network through said metering chamber (110); - an accelerometer (150) configured to measure an acceleration to which said gas meter (100) is subjected by generating corresponding acceleration values, each indicative of an acceleration value to which said gas meter (100) is subjected in a corresponding time; - a first memory register (160) configured to store a basic acceleration value corresponding to an acceleration value generated by the accelerometer (150) at a basic time corresponding to an installation of the gas meter (100) in an installation position at the site; - a pressure sensor (170) configured to measure a pressure inside said measuring chamber (110); - a control unit (115) configured to perform the following operations, when said gas meter (100) is installed at the site with the inlet duct (102(in)) coupled to the gas distribution network: - collecting a set of acceleration values corresponding to a set of times; - comparing the acceleration values collected with the basic acceleration value; - generating said acceleration alarm (230; 240) based on said comparison, only if both the following conditions C1 and C2 have occurred:C1. a difference between each collected acceleration value and the basic acceleration value is greater than an acceleration threshold; andC2. the collected acceleration values do not deviate from each other by more than a further acceleration threshold, in which said acceleration threshold is greater than said further acceleration threshold; in which said acceleration alarm being indicative of at least one between a displacement and a rotation of the gas meter (100) with respect to said installation position of the gas meter (100); - generating a disconnection alarm (260; 270) indicative of a disconnection of the gas meter (100) from the gas distribution network if both of the following conditions A1, A2 are met: - A1. the acceleration alarm has been generated, and - A2. a relative pressure between the measured internal pressure and an atmospheric pressure is less than a pressure threshold.

A method (200) for controlling and managing the connectivity of at least one gas meter (100) provided with an integrated e-UICC, in order to guarantee connectivity continuity for a data transmission to a remote acquisition system, of data and measurements indicative of gas deliveries generated by at least one gas meter (100) in a plurality of sites, even under at least one anomaly condition.

The invention is in the field of biomedicine; and relates to Lacticaseibacillus paracasei subsp. tolerans, and a specific strain or a variant thereof, and their use in the treatment of insulin resistance syndrome, polycystic ovary syndrome, insulin resistance related infertility, gestational diabetes, obesity, and proinflammatory conditions. The invention also relates to a biologically pure culture, or a composition, or a pharmaceutical product, or a feed, or a nutritional product, or a nutraceutical composition comprising the specific strain or variant thereof, and a cosmetic method comprising administering the specific strain, or the biologically pure culture, composition, pharmaceutical product, feed, nutritional product, or nutraceutical composition.

A gas meter (100) is provided. The meter comprises a battery capacity calculation system (115, FG(k)) configured to calculate a residual capacity of said one or more batteries (B(k)), the battery capacity calculation system (115, FG(k)) comprises at least one electronic measuring device (FG(k)) of a quantity of electric charge delivered by a respective one of said one or more batteries (B(k)), the electronic measuring device (FG(k)) is configured to periodically sample at least either the voltage or the current requested from the respective battery (B(k)) and to calculate a quantity of electric charge delivered by such battery (B(k)) on the basis of sampled values obtained from the periodic sampling of at least one between the voltage and the current. The battery capacitance calculation system (115, FG(k)) is configured to set a sampling frequency of the one electronic measuring device (FG(k)) to: - a first sampling frequency value, when the gas meter (100) is in a basic operating condition, and - a second sampling frequency value greater than the first sampling frequency value, when the gas meter (100) is in an extended operating condition.

The invention relates to a method for producing a trypsin-like protease in Bacillus, the method comprising expressing in a Bacillus host cell a gene coding for a preproenzyme comprising or consisting of (i) a trypsin-like protease having a sequence identity of at least 70% compared to the wild-type trypsin-like protease from the fungus Fusarium oxysporum, and (ii) preferably, a prosequence located upstream of the trypsin-like protease and having at its C-terminus a basic amino acid residue, and (iii) a bacterial secretion signal sequence located upstream of the trypsin-like protease and of the optionally present prosequence, wherein the bacterial secretion signal sequence is capable of directing secretion in a Bacillus host cell to a culture medium, thereby providing a culture medium comprising the mature trypsin-like protease.

A device (D) for toilet bowls comprising: - a first container (C1) comprising a first housing chamber for housing a first cleaning and/or deodorizing composition; - a second container (C2) comprising a second housing chamber for housing a second cleaning and/or deodorizing composition; - a third container (C3) comprising a third housing chamber for housing a third cleaning and/or deodorizing composition; - a hook (G) directly connected to said first container (C1) for securing the device to an edge of a toilet bowl; - a first bridge (P1) extending horizontally between the first container (C1) and the second container (C2), said first bridge (P1) forming a flexible region between said first container (C1) and said second container (C2); - a second bridge (P2) extending horizontally between the first container (C1) and the third container (C3), said second bridge (P2) forming a flexible region between said first container (C1) and said third container (C3), wherein said second container (C2) and said third container (C3) are positioned at the side with respect to said first container (C1).

An amorphous solid dispersion comprising dasatinib and one or more polymers; wherein the one or more polymers comprises a polymer that exhibits pH-dependent solubility.