K&L Gates LLP

A method and system for a brake controller configured to initiate a first emergency brake mode based on a manual input and a second emergency brake mode based on an automatic input. The brake controller comprises a plurality of electro-pneumatic brake valves coupled to pneumatic brake valves. The brake controller may be communicably coupled to a control circuit and/or an external brake system that communicate brake signals to control the plurality of electro-pneumatic brake valves and initiate the first and second emergency brake modes.

The present disclosure relates to a hydrogen storage system comprising a well extending below a ground surface, through external geology; an inner casing extending substantially the depth of the well to define a hydrogen storage chamber within the well, to store liquid hydrogen; and at least one outer casing extending substantially the depth of the well, to define an insulation chamber located between the hydrogen storage chamber and the external geology.

An endoscope system (1) includes an insertion unit (3) including a sensor (32) at a distal end (34) and being bendable and a control unit (50). The control unit receives a mode signal indicating a mode in which the insertion unit is automatically bent. The control unit acquires data output from the sensor. The control unit determines a gravitational direction (Dg) at the distal end based on the data. The control unit outputs a control signal for bending the insertion unit such that an angle (An) between a forward direction (Dif) of the distal end and the gravitational direction (Dg) increases after the mode signal has been received.

A power converter circuit may include a primary (EP) and a secondary (ES) stage. The primary stage may include a first primary winding (Tr1-P) connected in parallel with a first conversion stage (CPP1), and a second primary winding (Tr2-P) similarly connected with a second conversion stage (CPP2). Each of the first and second conversion stages may include a first primary switch (T1, T3) and first auxiliary switching circuit (CAC1, CAC3), and a second primary switch (T2, T4) and second auxiliary switching circuit (CAC2, CAC4). For each conversion stage, the first auxiliary switching circuit and the second auxiliary switching circuit may include a storage circuit (SC1, SC2, SC3, SC4) having a snubber capacitor (Cs1, Cs2, Cs3, Cs4) and diode (Ds1, Ds2. Ds3. Ds4), and a recirculation circuit (RC1, RC2, RC3, RC4) having a recirculation inductor (Lr1, Lr2, Lr3, Lr4), diode (Dr1, Dr2, Dr3, Dr4), and switch (T5, T6, T7,T8). The storage circuit (SC1, SC3) of the first auxiliary switching circuit (CAC1, CAC3) may be connected in parallel with the first primary switch (T1, T3), and the storage circuit (SC2, SC4) of the second auxiliary switching circuit (CAC2, CAC4) may be similarly connected with the second primary switch (T2, T4).

A friction shoe includes a backing plate, plural spaced-apart inserts, and a composite body. The backing plate has a top side, an under side, a long axis, and a cross axis that is perpendicular to the long axis. A width of the backing plate along the cross axis is shorter than a length of the backing plate along the long axis. The plural spaced-apart inserts are attached to the under side of the backing plate. The backing plate and plural inserts are integrally made of a metal material. The composite body is attached to the backing plate and at least partially disposed between and around the plural inserts.

The present disclosure provides for a piston reactor for depositing nanoparticles on structured substrates. According to one aspect of the present disclosure a piston reactor for depositing nanoparticles on structured substrates. According to a second aspect of the present disclosure a method of using a piston reactor for depositing nanoparticles on structured substrates.

The present disclosure provides a universal, high-throughput antibody discovery platform based on: (i) a negative-selection method for enriching B cells or plasma B cells without relying on plasma B cell surface biomarkers, and (ii) a microfluidic droplet-based functional screening system capable of identifying single cells secreting antigen-specific antibodies. The enrichment method employs a customizable cocktail of antibodies that target non-B lineage immune cells, followed by magnetic bead depletion. Enriched antibody-secreting cells are subsequently encapsulated into picoliter or nanoliter droplets together with (a) antigen-coated beads, (b) a fluorescent labeled antigen with immunoglobulin-capture antibody-coated beads, or (c) antigen-expressing reporter cells, allowing for functional detection of secreted antibodies inside each droplet. Through multi-channel fluorescence detection-incorporating detection antibody signals, dead-cell exclusion dyes, and optional blocking-antibody controls-droplets containing antigen-specific antibody-secreting cells are isolated. The recovered cells undergo single-cell BCR amplification or bulk BCR sequencing to obtain naturally paired heavy and light chain sequences.

A method of adding a neural beat having a beat frequency to digital audio comprises: receiving a digital audio file encoding music over a network or from a digital storage device; determining pitch characteristics of the digital audio file at a plurality of timestamps; selecting a time-varying carrier frequency for the neural beat based on the pitch characteristics at the plurality of timestamps; creating a modified version of the digital audio file configured to produce the neural beat having the beat frequency at the time-varying carrier frequency combined with the music when the digital audio file is played; and storing on the digital storage device or transmitting over the network the modified version of the digital audio file.

A control system is provided to receive a plurality of vehicle data from sensors in a vehicle communication network. The control system is disposed on a vehicle in a vehicle system and evaluates a plurality of components of the vehicle system with a predictive model associated with the sensor data. The control system may determine a vehicle status based on the predictive model and modify an operational plan or impose an operational restriction through a propulsion system of the vehicle.

A relay assembly is disclosed herein. The relay assembly can include a first relay with a first reset interface to reset an operating state of the first relay and a second relay with a second reset interface to reset an operating state of the second relay. The second relay can be positioned such that the second reset interface opposes the first reset interface of the first relay. The relay assembly can further include a mechanical armature positioned between the first reset interface and the second reset interface. The mechanical armature can be transitionable between a first position, wherein the mechanical armature is spaced apart from the first reset interface and the second reset interface in the first position, and a second position, wherein the mechanical armature engages the first reset interface and the second reset interface in the second position.