Purdylucey Intellectual Property

The present invention relates to computer-implemented methods and systems for characterising the microstructural composition of a blood vessel and the pathological features therein, utilising magnetic resonance quantitative susceptibility mapping and machine learning or Al models. Methods and systems providing explainable quantitative rupture risk assessment of plaques and aneurysm in target blood vessels, particularly carotid arteries, are disclosed. An advantage of the invention is to provide explainable plaque and aneurysm rupture, risk scores based on a single measurement sequence, resulting in a cost, time, and resource efficient risk assessment.

One aspect of the invention provides a method of contraception by administering to a female subject a composition comprising Mullerian inhibiting substance (MIS). The MIS can be produced endogenously in the subject by a vector, where the vector comprises a polynucletide encoding a recombinant MIS protein. In some embodiments, the contraception is permanent and only requires administration of the composition once. Another aspect of the invention relates to a method of preserving an ovarian reserve, the method comprising administering to a female subject a composition comprising MIS or an inducible vector that comprises a polynucleotide encoding a recombinant MIS protein.

A method of forming a composition comprising a probiotic encapsulated in a denatured plant protein matrix, comprises the steps of preparing a protein suspension comprising denatured plant protein, preparing a suspension of hydrated probiotic, combining the protein suspension and the suspension of hydrated probiotic to encapsulate the probiotic in a denatured pea protein matrix, and polymerising the denatured plant protein matrix with a calcium salt. The combining step may comprise extruding the protein suspension and the suspension of hydrated probiotic to form microdroplets, in which the polymerisation step comprises curing the extruded microdroplets in a curing bath comprising a calcium citrate buffer having a pH of 5 to 6.5 and a molarity of 0.05 to 0.15 M. The combining step may also comprise mixing the protein suspension and probiotic suspension to form a mixture, adding a calcium salt buffer to the mixture to gel the mixture, and drying the gelled mixture by freeze-drying or vacuum drying.

A system and method of generating a model M that can detect or predict the predisposition to an outcome, for example a person's predisposition to developing a health condition such as preeclampsia, with a positive or/and negative predictive value better or equal to a predefined predictive value target, where the method factors in the impact of prevalence on test performance. The system and method employ an iterative population segregation methodology, involving at least two population segregations steps in which each step, independently, employs a probability-defined model. The first segregation step is selected from one of a rule-in probability defined model and a rule-out probability defined model, and the second segregation step is selected from the other of a rule-in probability defined model and a rule-out probability defined model. The present invention overcomes the technical limitations of existing predictive models and provides a solution to achieve a superior predictive model delivering an accurate risk prediction result, and in a less computationally intensive way. By isolating and segmenting particular population subsets according to the invention a much more robust and accurate way of detecting, or predict risk of, an outcome is achieved.

A system for and method of monitoring/measuring the level of receptoral action/blockade and intra-ocular penetration/concentration of an eye medication and determining an optimal treatment regime based on the level of receptoral action/blockade and intra-ocular penetration/concentration of the eye medication.

Disclosed is a method of estimating an unoccupied area around a sensor. The method includes measuring a radar point cloud of a scene around the sensor, using the sensor; identifying a set of clusters within the radar point cloud; defining a boundary around each cluster to obtain a set of inner hulls corresponding to the set of clusters, defining a global point cloud boundary around an outer limit of the radar point cloud to obtain an outer hull, wherein the outer hull is formed by connecting a plurality of outer hull points; identifying a plurality of connecting edges of the outer hull, wherein each connecting edge is present in the outer hull, and absent in the plurality of inner hulls; forming a free space polygon by traversing through the plurality of inner hull points of each hull and the connecting edges, wherein the free space polygon indicates the unoccupied area around the sensor.

Embodiments enables a wearable phototherapy apparatus that produces beneficial effects to a human body such as anti-viral effects, activation of stem cells, improvement in strength, improvement in stamina, pain relief via a non-transdermal container. May include an optional transdermal container that releases or increases copper peptide GHK-Cu in a subject's body. The non-transdermal apparatus reflects or emits specific wavelengths of light to elevate levels of the copper peptide GHK-Cu in the body. The non-transdermal apparatus includes one or more materials that prevent the Left-Handed molecule from direct contact with the body while the enclosure is coupled to the body and prevents the Left-Handed molecules from entering the body. Embodiments may include or be used with any bioavailable form of copper, e.g., such as copper glycinate as an anti-viral therapy and may include an anti-inflammatory or both.

Disclosed is a system for monitoring and detecting anaesthetic gases in a sample gas, that includes a portable device that comprises: a gas detection chamber. The gas detection chamber includes a gas inlet, and a gas outlet, and a vacuum pump connected to the gas outlet for creating a vacuum in the gas detection chamber, thereby causing a flow of sample gas in the gas detection chamber, through the gas inlet, and first and second ends that comprise first and second IR transparent windows respectively. The portable device further comprises at least one IR emission source externally disposed opposite the first end, at least one detector externally disposed opposite the second end for receiving the IR light transmitted by the at least one IR emission source through the first and second IR transparent windows, and a processing unit that is configured to process the data detected by the at least one detector, wherein the processing unit determines the level of anaesthetic gas in the sample gas based on the IR light received by the at least one detector.

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