Massachusetts Institute of Technology

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The present invention relates to anchoring element for a joint implant, a joint implant and a method of fabrication thereof. Specifically, the anchoring element for a joint implant according to the present invention comprises a bone-facing surface designed for the attachment of the joint implant to a bone and a hydrogel-facing surface designed for the attachment to a hydrogel component, wherein at least part of the hydrogel-facing surface is designed as a porous triply periodic minimal surface. The bonding between the hydrogel and the anchoring element is achieved through chemical anchoring and mechanical hooking mechanisms.

The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA-targeting systems comprising a novel DNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA. Aspects of the invention in particular relate to Cpfl mutants having altered PAM specificity.

Methods and systems are disclosed for assisting in controlling inter-satellite communication links of a constellation of satellites orbiting the Earth. The constellation comprises n orbital planes and m satellites per orbital plane, wherein n and m are positive integer values, n ≠ m, n ≥ 3, and m ≥ 3. The method comprises outputting parameters usable to control satellites of the constellation to establish an inter-satellite communication link topology for transmission of user data, while aiming at reducing latency in the transmission of data through the constellation. Computer programs, computer program products, and computer-readable storage medium are also disclosed.

Disclosed herein are modified mRNAs with poly(A) tails containing one or more additional poly-A tails or 5' caps, which may be made by ligation of nucleic acids onto the 3' terminal end or 5' terminal end of an RNA, respectively. Also provided are compositions comprising one or more modified mRNAs provided herein, and methods of using said compositions for therapeutic or agricultural applications.

A device includes a grouping of N qubits, where N is equal to two or more, and a coherent light source configured to, given selected values for a set of parameters of at least a first and a second laser pulse, the parameters selected from a relative phase shift, a laser frequency, a laser intensity, and a pulse duration: apply at least the first and second laser pulses to all qubits within the grouping of N qubits, thereby coupling a non-interacting quantum state |1〉 to an interacting excited state |r〉, such that each qubit that begins in quantum state |1〉 returns to the state |1〉 upon completion of the at least first and second laser pulses, and such that qubits in the grouping are mutually blockaded.

Zusammenfassung wird geladen …

Zusammenfassung wird geladen …

Zusammenfassung wird geladen …

Zusammenfassung wird geladen …