Schaumburg und Partner Patentanwälte mbB

A chalcogenide glass includes Ga in an amount of 2.0 to 40.0% by mass; Sb in an amount of 20.0 to 75.0% by mass; S in an amount of 15.0 to 40.0% by mass; Na, K, Rb, and Cs in a total amount R [Na + K + Rb + Cs] of 0.05% by mass or more; and C1, Br, and I in a total amount X [C1 + Br + I] of 0.01% by mass or less.

A label for analysing a biological sample is provided. The label comprises a first label part comprising a first nucleic acid strand (106) and a second label part comprising a second nucleic acid strand (110). The first nucleic acid strand (106) and the second nucleic acid strand (110) are configured to form a duplex. The label further comprises at least one first labelling moiety (108) and at least one second labelling moiety (112), and the label further comprises at least one blocking nucleic acid strand (126, 128). In further aspects, a marker (100, 500, 600, 700, 1000) comprising the label and a respective method are provided.

A cryostat microtome (100, 500) comprises a cryostat chamber (104), a sample holder (106) arranged inside the cryostat chamber (104) and having an object head (108, 400) configured to hold a sample (102), a sectioning unit (110) arranged inside the cryostat chamber (104) and configured to section the sample (102), and a cooling system (114) having a first circuit (116) for cooling the cryostat chamber (104) and a second circuit (200) connecting the first circuit (116) with the object head (108, 400) for cooling the object head (108, 400). The first circuit (116) comprises at least 20 g and at most 100, 500 g of a working fluid having a GWP100, 500 of less than one, a compressor (120) arranged outside the cryostat chamber (104) and configured to compress the working fluid, and at least one evaporator (128, 134) arranged inside the cryostat chamber (104) and configured to cool the cryostat chamber (104) by evaporating the working fluid. The second circuit (200) comprises a heat transfer fluid and a pump (138) configured to move the heat transfer fluid through the second circuit (118, 200).

Eine variable Transportanordnung (200) zum Transport von Wertscheinen (13) zu einer Wertscheinstapeleinheit (206) einer Vorrichtung (100) zur Handhabung von Wertscheinen umfasst zumindest zwei Transportwegeinheiten (202, 204), die zusammen einen Transportweg (208) zum Transport der Wertscheine (13) bilden. Der Transportweg (208) erstreckt sich von einem Einlaufbereich (214) zu einem Übergabebereich (218) und die Wertscheine (13) sind in dem Übergabebereich (218) an die Wertscheinstapeleinheit (206) übergebbar. Die zumindest zwei Transportwegeinheiten (202, 204) sind zueinander beweglich angeordnet. Weiterhin ist zumindest eine der Transportwegeinheiten (202, 204) zumindest zwischen einer ersten Betriebsposition und einer zweiten Betriebsposition bewegbar und der Übergabebereich (218) ist entsprechend bewegbar. In weiteren Aspekten werden ein Ein- und Ausgabefach (600), eine entsprechende Vorrichtung (100), sowie ein Steuerungsverfahren angegeben.

A modular capture construct (100, 900, 1000) for capturing a plurality of analytes (402, 504, 604, 706) of a biological sample (1300, 1408) is provided. The modular capture construct (100, 900, 1000) comprises a plurality of modules (102a, 102b, 102c), and at least a first dye (112) and a second dye (114) arranged on the capture construct (100, 900, 1000) to provide an orientation indication. The modular capture construct further comprises at least a first plurality of capture regions (108a, 108b, 108c, 108d, 108e, 108f), each capture region (108a, 108b, 108c, 108d, 108e, 108f) comprising at least one affinity capture reagent (400, 502, 602, 702, 704) configured to capture one of the analytes (402, 504, 604, 706), wherein each module (102a, 102b, 102c) comprises at least one of the capture regions (108a, 108b, 108c, 108d, 108e, 108f) of the first plurality of capture regions (108a, 108b, 108c, 108d, 108e, 108f). Each module (102a, 102b, 102c) comprises a nucleic acid backbone (201). Further, each of the modules (102a, 102b, 102c) is hybridised to at least another one of the modules (102a, 102b, 102c). In a further aspect, a method for detecting a plurality of analytes of a biological sample by means of the modular capture construct is provided.

A hybrid automated manual transmission includes an input shaft configured to be connected to a prime mover by an input clutch. At least one splitter gear is connectable to the input shaft. A main shaft is coaxial with the input shaft. At least two main shaft gears are connectable to the main shaft. At least one countershaft has at least one first driven gear drivingly engaged with the at least one splitter gear and at least two second driven gears drivingly engaged with the at least two main shaft gears. A motor generator drivingly connected to the input shaft by a reduced gear ratio and a motor generator clutch.

In a first aspect, a microscope stage (100, 500, 600) is provided comprising a receiving surface (102) configured to receive at least a first sample carrier (104, 200) with a plurality of sample areas (202, 204), an imaging area (206), and a surface moving device (118) configured to move the receiving surface (102) along at least two directions, wherein the surface moving device (118) has a range of movement along the at least two directions such that any one of the sample areas of the plurality of sample areas (202, 204) is alignable with the imaging area (206). The microscope stage further comprises at least one liquid handling head (106, 502, 602) configured to dispense fluids onto the sample carrier (104, 200), and a head moving device (108, 110, 112) configured to move the at least one liquid handling head (106, 502, 602) along at least two directions, wherein the head moving device (108, 110, 112) has a range of movement along the at least two directions such that the at least one liquid handling head (106, 502, 602) is alignable with any one of the sample areas (202, 204) of the plurality of sample areas (202, 204). In further aspects a corresponding microscope and method are provided.

A controller (142) for a laser microdissection system (100) is configured to receive a user input corresponding to first settings for the laser microdissection system (100) used with a first objective lens (114a), to generate second settings for the laser microdissection system (100) used with a second objective lens (114b) based on the first settings, and to configure the laser micro dissection system (100) based on the second settings. At least one characteristic of a first laser beam generated according to the first settings by the laser microdissection system (100) using the first objective lens (114a) is the same for a second laser beam generated according to the second settings by the laser microdissection system (100) using the second objective lens (114b). The at least one characteristic is influenced by the first objective lens (114a) when the laser microdissection system (100) is used with the first objective lens (114a) and influenced by the second objective lens (114b) when the laser microdissection system (100) is used with the second objective lens (114b).

A laboratory apparatus (100) for handling a sample tube (114) comprises a clamping device (102) having at least two clamping arms (108, 110) configured to be moved to a closed state for clamping the sample tube (114) arranged in a working space (W) therebetween and to be moved to an open state for releasing the sample tube (114) in the working space. Each clamping arm (108, 110) comprises a contact area (128, 130) configured to be in contact with the sample tube (114) in the closed state and to be out of contact with the sample tube (114) in the open state. At least one of the clamping arms (108, 110) further comprises a mechanically biased pushing member (140, 142) which is retractable against a biasing force upon contact with the sample tube (114) arranged in the working space (W) when the clamping arms (108, 110) are moved from the open state to the closed state, and which is extendable by the biasing force to push against the sample tube (114) and prevent the sample tube (114) from being pulled out of the working space (W) due to unintentional adhesion to the contact area (128, 130) when the clamping arms (108, 110) are moved from the closed state to the open state.

A method for imaging flow cytometry and corresponding imaging system (100, 200) are provided. The method comprises the step of moving a sample (116) along an axis of movement (118). The method further comprises the step of generating recorded images (300, 400) of the sample (116). Each recorded image (300, 400) is generated by illuminating the sample (116) by illumination light (106), forming an image of the sample (116) by collecting detection light (104) originating from the sample (116), and recording the recorded image (300, 400) of the sample (116) during its movement. The method further comprises the step of generating a combined image (308, 408, 502, 706) of the sample (116). The combined image (308, 408, 502, 706) of the sample (116) is generated by selecting at least two recorded images (300, 400). For each selected recorded image, a transformed recorded image (304, 404, 500) is generated by extracting at least a part of the selected recorded image, and a transformation is applied to the extracted part of the selected recorded image. The transformed extracted parts are combined into the combined image (308, 408, 502, 706).