Krauss, Jan

The present invention relates to antigen binding proteins that specifically bind to a MAGE-A4 antigenic peptide wherein said antigenic peptide is in a complex with a major histocompatibility complex (MHC) protein. The present invention further relates to nucleic acid molecules encoding a binding agent, vectors comprising the nucleic acid molecules, or recombinant or genetically modified cells comprising and optionally expressing the nucleic acid molecule or vector. The invention further relates to pharmaceutical compositions comprising the antigen binding proteins, nucleic acids, vectors or cells in accordance with the invention, and their use as a medicament in the prevention or treatment of treatment of a cancer and/or a metastasis thereof.

The present invention relates to a device (10) for a mechanical confinement of at least one cellular sample (4), comprising a support (1), at least one spacer (2, 2a) of a predefined height and thereby defining a confinement space at the bottom of the support (1), and at least one actuator (3) to be inserted into the support (1), the actuator (3) comprising a surface that provides a confinement of at least one sample (4) positioned in the confinement space. The present invention further relates to an array comprising a multitude of devices (10) according to the invention arranged on a carrier matrix, a method for exerting mechanical confinement to a cellular sample using the device (10) according to the invention, and a method for detecting the effects of mechanical confinement on a cellular sample using the device (10) according to the invention.

The present invention relates to a non-autologous mammalian split-thickness skin graft material for use in the treatment of a subject with deficient and/or missing attached gingiva. Further provided is a kit comprising the non-autologous mammalian split-thickness skin graft material and uses thereof.

A defibrillator housing with secure wire arrangement is provided. Four walls are each affixed on one side of a bottom surface. A dividing layer is affixed to each of the four walls creating an electrode enclosure configured to hold a pair of pads each associated with a wire, and a circuit enclosure configured to hold circuitry. Access to the circuitry is restricted by the bottom surface and dividing layer. A plug is positioned in the dividing layer and has at least one pin that extends through the dividing layer to connect with the circuitry in the circuit enclosure. The wires are connected to one end of the plug, opposite the pins, to provide power to the pads.

A sitting mat according to an embodiment of the present disclosure may include a base portion comprising a first base configured to define a seating portion and a second base formed around the seating portion, and an air mat surrounded by the second base, in which the air mat includes at least one air cell configured to be changed in volume by air pressure, thereby allowing a hybrid structure to stably support a buttock and a femur and maximizing a pressure dispersion effect.

The present invention relates to a method for producing a desired linear combined DNA molecule, linear or circular DNA plasmid using at least one genetically altered E. coli strain, wherein linear DNA fragments are converted into a linear combined DNA molecule or circular DNA plasmid. The method can be performed in vivo or in vitro, in particular as a single step method. The invention further relates to a method for cloning a nucleic acid fragment of interest, comprising the method according to the present invention, specific genetically altered E. coli strains, a kit for performing the method according to the present invention, and the use of the genetically altered E. coli strains, or the kit for producing a linear combined DNA molecule or circular DNA plasmid or cloning a nucleic acid fragment of interest.

Zusammenfassung wird geladen …

Zusammenfassung wird geladen …

Zusammenfassung wird geladen …

Zusammenfassung wird geladen …