Albert-Ludwigs-Universität Freiburg

A curable composition comprising a polythiol prepolymer (B) having at least two groups of formula <img class="EMIRef" id="088278b5-b93b-4d19-9ea0-5257520a5931-ia01" /> is provided, wherein n is 0 to 20, obtainable by using an oxathiolanone group-containing compound (A2), and a curing agent having an SH-reactive group. The oxathiolanone group-containing compound (A2) is used as a monomer for stabilizing a polythioether polymer (D) towards chemicals, preferably acids. The curable composition may be used upon hardening as a coating, as an adhesive, as a sealant or as a shaped article.

The present invention relates to a nanopore device (10), in particular a nanopore array device, comprising: a substrate (30); one or more nanopores (20) in said substrate; a first fluid compartment (40) arranged at a first side of the substrate, wherein the first fluid compartment is fluidically coupled to the one more nanopores (20) from the first side; a first electrode (61) adapted to be electrically coupled to the first fluid compartment (40); wherein the nanopore device (10) is configured for formation of a pinned droplet (71, 72, 73) at at least one of said one or more nanopores (20) at a second side of the substrate (30), wherein the second side of the substrate is opposite to the first side of the substrate; and one or more second electrodes (81, 82, 83) adapted to be electrically coupled to the one or more pinned droplets (71, 72, 73) at said one or more nanopores (20). The present invention further relates to a corresponding system (11) and method (100) for operating a nanopore device.

The present invention relates to a method for producing a display complex, the method comprising (I) providing a covalent mRNA-Puromycin Linker conjugate; (II) contacting the covalent mRNA-Puromcyin linker conjugate with an in vitro translation composition to produce a display complex comprising a polypeptide encoded by said mRNA, (III) optionally reverse transcribing said mRNA to a cDNA, and (IV) cyclisation of the polypeptide comprised in said display complex.

The present invention relates to a method for producing an electrochemical cell, comprising the step of adding an additive comprising or consisting of a compound represented by the formula (I) wherein R¹ to R⁶ are each independently from each other H, an alkyl group having 1 to 12 carbon atoms, or an alkoxy group having 1 to 12 carbon atoms, to an electrolyte in an electrochemical cell.

The present invention relates to porous carbon structure comprising one or more sets of porous spherical carbon particles, wherein each of said one or more sets of porous spherical carbon particles has a monomodal, bimodal or multimodal particle diameter distribution, and/or a monomodal, bimodal or multimodal templated pore size distribution, wherein each mode of said particle diameter distribution defines a subset of porous spherical carbon particles within the set, each subset having a particle diameter dispersity (d) of 1.2 or less, and wherein each mode of the templated pore size distribution defines a subset of porous spherical carbon particles within the set, each subset having a templated pore size dispersity (d') of 1.2 or less. The invention further relates to methods for producing the porous carbon structures of the invention, electrodes made from such structures and their use in various applications.

Die vorliegende Erfindung betrifft ein Verfahren sowie eine Strahlungsquelle zum Erzeugen einer elektromagnetischen Nutzstrahlung mit einer abstimmbaren Nutzfrequenz. Dabei umfasst das Verfahren die Schritte: Erzeugen einer elektromagnetischen Seed-Strahlung mit einer Seed-Frequenz mit einem Laser, Einkoppeln der Seed-Strahlung in einen optischen Ring, Modulieren der Seed-Strahlung in dem optischen Ring mit einer Modulationsfrequenz, sodass der Seed-Strahlung eine Mehrzahl von Seitenbändern aufgeprägt wird, wobei ein Frequenzabstand jedes aus der Mehrzahl von Seitenbändern von der Seed-Frequenz gleich einem ganzzahligen Vielfachen der Modulationsfrequenz ist, Verstärken der Mehrzahl von Seitenbändern in dem optischen Ring, Filtern der Mehrzahl von Seitenbändern mit einem Bandpass, sodass genau ein Seitenband, dessen Frequenzabstand von der Seed-Frequenz gleich dem Produkt aus einer ganzen Zahl größer als 1 mit der Modulationsfrequenz ist, als die elektromagnetische Nutzstrahlung bereitgestellt wird, und Auskoppeln der Nutzstrahlung aus dem optischen Ring.

The present disclosure relates to a microvalve and a microvalve array comprising one or more such microvalves designed according to the present disclosure. A microvalve comprises a base body with a cavity and at least one first opening and at least one second opening, each opening extending into the cavity, a deflectable membrane, which separates the cavity into a first chamber and a second chamber, an actuating element, which is supported by the base body and which contacts the deflectable membrane and is operable to deflect the membrane to move between at least two positions, wherein the deflectable membrane comprises at least one through-hole extending between the first chamber and the second chamber.

The invention relates to methods for determining whether a subject is a responder or a nonresponder to breast cancer therapy, in particular neoadjuvant breast cancer therapy.

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Zusammenfassung wird geladen …