JD&P Patent Attorneys Joanna Dargiewicz & Partners

The subject of the invention is a method for analyzing a biological material sample using a pipetting station to detect mosaic genetic variants at a very low frequency in genes. The method involves the isolation of DNA from a peripheral blood sample, followed by the preparation of DNA libraries for duplex sequencing and subsequent bioinformatic analyses. The method is characterized in that: a) DNA samples are prepared and mechanical DNA fragmentation is performed using an ultrasonic device; b) The resulting DNA fragments of approximately 500 base pairs undergo enzymatic reactions, adapter ligation, incubation, and purification using magnetic beads, where the enzymatic reactions include repairing the ends of fragmented DNA, ligation of the dedicated adapters, and amplification using PCR; c) Amplification and hybridization of dedicated molecular probes targeting the human genome region are carried out; d) The quality and quantity of the obtained DNA libraries are verified, followed by sequencing. The results are analyzed using bioinformatic tools, producing a list of genetic variants along with their frequency in the studied gene(s). Steps b) and c) of the method are performed using the Bravo NGS pipetting station from Agilent Technologies.

A layout structure for a sensor, a head, and a neck of a robot, includes a head, a neck, and a sensor. The neck is connected between the head and a torso. A lower portion of the neck is inclined forward such that a forward-open layout space is formed between a front side of the neck and a chin of the head. The sensor is arranged in the forward-open layout space. In a horizontal plane, the neck blocks less than 90° of a circumferential field of view of the sensor, which reduces the obstruction of the neck structure to the sensor and thus significantly enhances the environmental perception capability of a robot.

The present invention relates to Vitamin B12 monomer having the structure represented by the formula 4 or 3, a method of synthesis of Vitamin B12 monomer having the structure represented by the formula 4 or 3, a method of synthesis of nanogels modified with Vitamin B12 using precipitation polymerization, a use of the nanogel modified with Vitamin B12 in drug delivery systems, a pharmaceutical composition comprising nanogel modified with Vitamin B12 and active ingredient, and a pharmaceutical composition comprising nanogel modified with Vitamin B12 and active ingredient for use in the treatment of cancer.

A joint structure is configured to connect a proximal limb and a distal limb. The joint structure includes a first motor, an adapter bracket, and a second motor. The first motor is configured to be arranged inside the proximal limb. The adapter bracket includes a connection portion and a support portion. An upper end of the connection portion is connected to an output shaft of the first motor. A lower end of the connection portion is connected to the support portion. The support portion is located below the proximal limb. The second motor is arranged inside the support portion and an output shaft of the second motor extends out of the support portion and is connected to the distal limb. An axis of the first motor is perpendicular to an axis of the second motor, such that proximal housings of the proximal limb remain continuous and intact.

A radio frequency power amplifier includes a supporting substrate and a first amplifying branch. The supporting substrate is provided with a ground terminal. The first amplifying branch includes a first connection terminal, a second connection terminal, a first impedance matching network, a second impedance matching network, a first transistor and a first parasitic capacitance resonance network. The first transistor includes a gate and a drain. The first impedance matching network is electrically connected between the first connection terminal and the gate of the first transistor. The second impedance matching network is electrically connected between the drain of the first transistor and the second connection terminal. The first parasitic capacitance resonance network is electrically connected between the drain of the first transistor and the ground terminal. Compared with the prior art, the amplification efficiency of the radio frequency power amplifier can be improved.

A head structure for a humanoid robot includes a head frame, a motor bracket, and a pitch motor. The motor bracket includes a first fixing side plate and a second fixing side plate facing each other, and the first fixing side plate and the second fixing side plate are each configured to be connected to a neck structure. The pitch motor is fixed between the first fixing side plate and the second fixing side plate. The head frame is rotatably connected to the first fixing side plate. An output shaft of the pitch motor penetrates through the second fixing side plate and is connected to the head frame. An axis of the pitch motor is arranged to pass through a center of gravity of the head structure, thereby improving the stability of the head structure.

The present utility model relates to the technical field of coffee machines, and specifically discloses a telescopic container assembly and a coffee machine. The assembly comprises a mounting bracket (1) and a cup (10), with the cup (10) sleeved on the outer side of the mounting bracket (1). A receiving space for accommodating liquid is formed between the cup (10) and the mounting bracket (1), and an adjustment component is arranged between the mounting bracket (1) and the cup (10) for enlarging or reducing the receiving space. Through the provision of the adjustment component, the receiving space can be increased or decreased, allowing the size of the receiving space to be flexibly adjusted as needed. Moreover, when not in use, the receiving space can be reduced, making the device easier to carry.

A parking heater includes a housing (10) with an air inlet (11) and an air outlet (12), a combustion chamber (20) arranged in the housing (10) and a heat-exchange member (30). The combustion chamber (20) includes an open end (21) and a closed end (22). The open end (21) faces the air outlet (12) and includes a high side (211) and a low side (212), an end surface of the open end (21) is a sloping surface, and a combustion portion (221) is arranged at the closed end (22). The heat-exchange member (30) is configured as a hollow structure and arranged between the housing (10) and the combustion chamber (20). A gas inlet (31) and a gas outlet (32) are formed in a side wall of the heat-exchange member (30), the gas inlet (31) communicates with the combustion portion (221), and the gas outlet (32) is located a side of the heat-exchange member (30) adjacent to the high side of the open end (21), which allows high-temperature gas to uniformly contact the heat-exchange member (30), and the effective contact area between the high-temperature gas and the heat-exchange member (30) is greatly increased, thus increasing the heat utilization rate and improving the heating performance of the parking heater.

The device consists of a case (1) made of heat conductive material, from which two pins or electrical connectors emerge: an input pin (2) and an output pin (3), which are connected in series with a diode (4), a resistor (5) and an electric thermostat (6) which closes the circuit upon reaching a preset temperature. The input pin determines a means of connection to the live or neutral cable in the socket outlet or plug in question, while the output pin (3) determines a means of connection to the earth cable in the socket outlet or plug in question. The diode (4) establishes a single direction of flow of the current through the device to the neutral connection, which serves to prevent overheating in socket outlets and plugs, in order to avoid potential fires.

The disclosure provides a dispersion-blending based particle size-improved lithium battery ceramic separator powder preparation method and an apparatus thereof. The aforementioned dispersion-blending based particle size-improved lithium battery ceramic separator powder preparation method includes transporting a first raw material to a sand mill assembly to obtain a first powder; performing a complex grinding inspection operation on the first powder. The complex grinding inspection operation includes: inspecting the first powder to obtain a first particle size parameter; determining whether the first particle size parameter is greater than a preset particle size parameter; transporting the first powder to a powder buffer tank to form a second powder, if the first particle size parameter is greater than the preset particle size parameter, and dispersing and mixing a second raw material and the second powder according to a dynamic blending ratio to have the second powder enter the sand mill assembly together with the second raw material for grinding, so that the raw material of the previous process can be ground timely, and the material obtained through grinding the raw material can enter the equipment of the next process, thereby reducing the impact of repeated grinding of powder on the rhythm and efficiency of the production line.