Appleyard Lees IP LLP

Inhibitors of CDK9 that are pyrazolo[1,5-a]pyrimidine derivatives and salts thereof, corresponding to formula (I):

The present techniques provide a method, apparatus and system for using high-speed acoustic levitation in printing. A novel technique is presented that allows high-speed multi-point levitation even in the presence of the printed sound-scattering object. Embodiments provide a simplified approach for determining locations of traps in a working volume which may also be termed an acoustic volume or acoustic chamber.

A cut guide assembly (600) and a system for mounting assembly on a patient are described. The system includes an ankle clamp (525), an alignment guide (530) configured to be removably attached to the ankle clamp, and the cut guide assembly. The cut guide assembly includes a cut guide (535) and a position tracker (200). The cut guide includes a receiving feature (605) configured to removably attach to at least a portion of the alignment guide, a locking mechanism (610) configured to lock the receiving feature to the at least a portion of the alignment guide, and a plurality of pin receptacles (620), each of the plurality of pin receptacles configured to receive a bone pin (540) configured to affix the cut guide to a patient's bone. The position tracker configured to be affixed to the cut guide when the cut guide is affixed to the patient's bone.

A bone plate (100) incorporating a length adjusting elongate hole (130) formed in a shaft portion (115) thereof, along with corresponding methods of use, are disclosed herein. In one embodiment, the length adjusting elongate hole (130) is arranged and configured to receive one or more bone fixation devices (e.g., bone screws). In use, the bone fixation device positioned within the length adjusting elongate hole (130) may be partially loosened, without removal, to enable the patient's bone to be adjusted (e.g., loosening the bone fixation device within the length adjusting elongate hole allows the surgeon to adjust the position of the patient's bone, and hence the bone fixation device coupled thereto, relative to the bone plate). Once properly adjusted, the bone fixation device positioned within the length adjusting elongate hole (130) may be retightened. In various embodiments, the length adjusting elongate hole (130) is arranged and configured so that, in use, each of the plurality of bone fixation openings remains available to a surgeon.

A downhole instrument includes an instrument housing, a sensor yoke rotatably mounted within the instrument housing, and an angular rate sensor carried by the sensor yoke. A first rotational stop is mounted to the instrument housing that defines a first rotational position of the sensor yoke. A second rotational stop mounted to the instrument housing defines a second rotational position of the sensor yoke that is rotationally spaced from the first rotational position. A differential screw may be connected to the second rotational stop that is adapted to adjust a position of the second rotational position. A torsion coupling may be coupled between the rotational driver and the sensor yoke, where the torsion coupling is energized by the motor that rotates the sensor yoke with a returning force that resists movement of the sensor yoke away from the first rotational stop.

An electronic device capable of being arranged in a folding state including a fully folded state, a partially folded state and a fully unfolded state may comprise at least one processor including processing circuitry and memory storing instructions. The instructions may, when individually or collectively executed by the at least one processor, may cause the electronic device to display, in the fully folded state, a first screen of a first application through the second display, based on identifying a first change from the fully folded state to the partially folded state, identify at least one artificial intelligence function associated with execution of the first application, and display, in a display area of the first display visually exposed in the partially folded state, a second screen including a user interface (UI) indicating the at least one AI function, and based on a first user input for selecting a first AI function among the at least one AI function, apply the selected first AI function to the first application. Other various embodiments are also available.

Disclosed are an electronic device and a control method of an electronic device. In particular, the control method of an electronic device according the disclosure comprises the steps of: acquiring a plurality of images through at least one camera; inputting RGB data for each of the plurality of images into a first neural network model to obtain two-dimensional pose information on an object included in the plurality of images; inputting RGB data for at least one image of the plurality of images into a second neural network model to identify whether the object is transparent; if the object is a transparent object, performing stereo matching based on the two-dimensional pose information on each of the plurality of images to obtain three-dimensional pose information on the object; and if the object is an opaque object, acquiring three-dimensional pose information on the object based on one image of the plurality of images and depth information corresponding to the one image.

An electronic apparatus communicating with a display apparatus including a plurality of display modules is disclosed. The electronic apparatus includes an Ethernet switch, and a processor connected to the Ethernet switch and including a virtual Ethernet port to which an IP address is pre-allocated, wherein the processor is configured to configure a network with an external electronic apparatus based on the pre-allocated Internet Protocol(IP) address, and based on a signal for setting a screen of a display module connected to a port of the Ethernet switch being received from the external electronic apparatus through the network, control the Ethernet switch to transmit the signal for setting the screen to the display module.

Methods generate a dynamic real-world environment with at least one interactive ARBit. Environment information captured from a real-world environment is received from a mobile computing device. The environment information is processed to determine identified features corresponding to the real-world environment and the dynamic real-world environment is generated based upon the identified features. An ARBit database is searched for ARBits that match the identified features and the matched ARBits are added to an ARBit collection. The dynamic real-world environment and the ARBit collection are sent to the mobile device. A user of the mobile device interacts with the dynamic real-world environment and at least one displayed ARBit of the ARBit collection.

We describe a method and system for detecting pathogens in a sample, particularly an air sample. The method is designed to run in real-time alongside sequencing processing of the sample so that results are quickly available to a user. Each input sequence read in the plurality of sequence reads is compared using a first classification algorithm and assigned to a taxon. An input sequence is classified as potentially pathogenic when the taxon to which the input sequence read is assigned corresponds to a pathogen taxon. Each input sequence read classified as potentially pathogenic is compared using a second classification algorithm to a plurality of target sequences in a second database which is selected based on the pathogen taxon. A confidence score is used as part of the decision-making process to decide if an individual read represents a genuine match to a pathogen.