Seoul National University R&DB Foundation

The present disclosure relates to a method for healing a metallic glass and a metallic glass healable thereby, and more specifically, to a healing method which, based on a time-temperature transformation curve showing the structural relaxation and crystallization onset of a metallic glass, may standardize the structural changes resulting from process variables of the metallic glass through heat treatment for structural relaxation at a specific healing temperature, followed by quenching, and heal structural damage caused by elastic and plastic deformation of the metallic glass, thereby enabling restoration of strength as well as repeated restoration of deformation stability properties such as ductility and toughness, and a metallic glass healable by the method.

The invention relates to the field of medicine, in particular to means and methods for the improvement, prevention or treatment of osteoarthritis. Provided is an oligonucleotide specifically hybridizing with miR-204 and a composition for ameliorating, preventing, or treating osteoarthritis, including the same. The oligonucleotide includes 20 to 22 linked nucleotides and consists of a first region, a second region, and a third region in order from a 5' end to a 3' end, wherein the first region includes three consecutively connected nucleotides, each complementary to a tail region of miR-204 and including a constrained sugar modification, the second region includes three connected nucleotides connected, the nucleotides included in the second region each independently being nucleotides including a constrained sugar modification or a non-constrained 2'-substituted sugar modification, and the third region includes a plurality of connected nucleotides, the nucleotides included in the third region each independently being nucleotides including a non-constrained 2'-substituted sugar modification, and wherein the oligonucleotide includes 30% or less of nucleotides including a constrained sugar modification based on a total number of nucleotides.

The present invention relates to a nonlinear unitary optical device. The nonlinear unitary optical device includes a first nonlinear unitary unit of one dimension positioned on an upper optical channel, a second nonlinear unitary unit of one dimension positioned on a lower optical channel, and an interferometer configured to couple the first nonlinear unitary unit and the second nonlinear unitary unit.

The present disclosure provides a federated continual learning method for a large multimodal model, comprising steps of: inputting at least one training data to the m-th local large multimodal model to (i) generate an embedding vector, (ii) (ii_1) generate an (m_1)-th local prompt vector and an (m_1)-th global prompt vector, and merge the (m_1)-th local prompt vector and the (m_1)-th global prompt vector to thereby generate an (m_1)-th merged prompt vector, and (ii_2) generate a first hidden status vector, (iii) (iii_1) generate an (m_j)-th local prompt vector and an (m_j)-th global prompt vector, and merge the (m_j)-th local prompt vector and the (m_j)-th global prompt vector to thereby generate an (m_j)-th merged prompt vector, and (iii_2) generate a j-th hidden status vector, and (iv) repeat learning iteration to the training data; and transmitting updated information of the local prompt generators to thereby update the global prompt generators.

Disclosed herein may be apparatus (100) and method for separator (11) heat-sealing and stacking. The apparatus (100) may include a continuous separator supply unit (110) configured to connect a plurality of separator rolls (111) and supply separators (11) in the form of continuous sheets, a heat-sealing unit (120) configured to heat-seal two sheets of separators (11) supplied from the continuous separator supply unit (110), an electrode plate inserting unit (130) configured to insert an electrode plate (21, 22) between the two sheets of heat-sealed separators (11), and a cutting unit (140) configured to cut the two sheets of separators (11) between which the electrode plate (21, 22) is inserted, and produce a unit pack (30).

A method for preparing a single-particle type positive electrode active material precursor includes (a) mixing a nickel-based hydroxide and an inactive lithium salt to prepare a mixture; and (b) performing a first heat treatment on the mixture to obtain a nickel-based oxide in a form of single particles. According to some example embodiments, a positive electrode active material precursor and a method for preparing the same, and a method for preparing a positive electrode active material including the same minimize or reduce the production process, thereby ensuring long cycle-life characteristics and improving high-temperature storage characteristics. A rechargeable lithium battery using the positive electrode active material can exhibit high initial charging and discharging capacity and efficiency, and can implement long cycle-life characteristics.

A positive electrode active material, a method for preparing the positive electrode active material, a positive electrode including the positive electrode active material, and a rechargeable battery (e.g., a rechargeable lithium battery) including the positive electrode are disclosed. The positive electrode active material may have a disordered rocksalt structure. The positive electrode active material includes a compound represented by Chemical Formula 1, wherein a ratio of M<1> having an oxidation number of +2 is less than or equal to about 25 at%, based on a total of 100 at% of M<1>.

The present invention provides a composition for inhibiting ice recrystallization, including: A nucleic acid structure comprising a scaffold nucleic acid folded at predetermined positions to form a plurality of strands, and a plurality of staple nucleic acids, wherein at least a portion thereof has a complementary sequence to at least a portion of the scaffold nucleic acid, thereby binding to the scaffold nucleic acid to form a double strand. Therefore, it is possible to increase a survival rate of cells due to having excellent effect of inhibiting ice recrystallization upon cryopreservation of the cells, and maintain a texture of food even when using the composition in the freezing of food.

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An apparatus and method for optimizing a subsurface velocity model are provided to be able to optimize a velocity model by applying the Gauss Newton method through parameterization of the velocity model in exploration seismology.