Université Paris-Saclay

La présente invention concerne des bactéries pour leur utilisation chez un enfant et/ou sa mère, au moins au cours de la période allant de la naissance dudit enfant jusqu'aux deux ans révolus dudit enfant, dans la prévention ou le traitement des effets délétères chez ledit enfant résultants de maladies non transmissibles qui sont observées, à moyen et/ou long termes, après une dysbiose du microbiote en âge précoce (correspondant à la primo-colonisation).Ces bactéries sont choisies parmi les souches primo-colonisatrices d'un microbiote non dysbiotique, appartenant à un genre choisi parmi Bifidobacterium ou Limosilactobacillus.

La présente invention concerne un mélange m(C) comprenant un mélange de sels de chlorures fondus, que l'on peut par exemple utiliser dans le domaine de l'énergie comme le nucléaire et/ou le solaire. La présente invention concerne en outre des procédés de préparation d'un mélange comprenant un mélange de sels de chlorures fondus et un dispositif comprenant un élément configuré pour contenir ou faire circuler le mélange m(C) selon la présente invention, ou le mélange obtenable ou obtenu selon les procédés de la présente invention, l'élément ayant une paroi comprenant un ou plusieurs métaux parmi Fe, Ni et Cr en contact avec ledit mélange.

The present invention relates to a genetically modified Bacillus thuringiensis strains having an improved spectrum of action against insect crop pests and its use as a biopesticide. More specifically, these strains are such that they do not form viable and resistant spores and do not express endogenous N-acetylmuramoyl-L-alanine amidases regulated by VipR.

The invention relates to a method for quantitatively and temporally characterizing particles of a plasma by means of a probe, the plasma comprising at least ions and neutrals. The method comprises:- applying several plasma pulses,- for each plasma pulse considered, applying a bias pulse consisting in applying a bias voltage on the probe, this voltage being intended to prevent the ions from reaching the probe.The total plasma duration is partitioned into N parts or time-steps of duration δT, the method further comprising the following steps:- for each plasma pulse considered, a bias pulse is applied with a temporal overlap zone between the plasma pulse and the bias pulse, the temporal overlap zone being different on each application of a bias pulse, the temporal overlap zones sweeping the entire total plasma duration in steps of duration δT,- for each plasma pulse considered, carrying out, over at least the entire total plasma duration, a quantitative measurement Qn of the ions and neutrals reaching the probe, n ranging from 1 to N.

The present invention concerns novel synbiotic microcapsules of enhanced storage stability at room temperature. The symbiotic microcapsules are produced in a single step by spray drying, and present a microcapsule composition consisting essentially of a probiotic, and a mixture of a prebiotic preferably inulin, maltodextrin, and a protective colloid selected from the group consisting of gum Arabic, starch, rice starch, modified starches, pectin, xanthan gum and mixtures thereof. The invention also proposes a spray drying process easy to operate and providing excellent encapsulation and efficiency yields. The synbiotic microcapsules have proven to effectively protect the encapsulated probiotic during gastrointestinal transit and to provide a probiotic effect on in vitro and in vivo essays.

The invention relates to the proteins Agrin, Zyxin, Synaptotagmin-5, and combinations thereof, as well as the gene transcripts form the corresponding genes, as biomarkers of a hypoxic-ischemic encephalopathy (HIE).

The present invention relates to novel antibody conjugates containing chimeric or humanized antibodies (or fragments thereof) that are able to recognize specifically the human Endothelin B receptors expressed on tumor cells, said antibodies or fragments carrying at least two functional molecules that are cytotoxic and / or detectable. The invention also relates to the use of such bifunctionalized antibody conjugates as diagnostic agents and/or as medicaments, for detecting and/or treating patients suffering from melanoma and other cancers in which the human endothelin B receptor is overexpressed, such as glioblastoma, bladder cancer, lung cancer, kidney cancer, or vulvar cancer.

The invention relates to a method for reducing latency in video transmission, using an input video sequence and a neural network that accounts, at the encoder side, for dynamic objects, the method comprising: i. initializing the neural network with a warm-up training for frames I0,l,I0,r ...IN,l,IN,r with Ii,j denoting a frame in the input sequence and j∈{l,r} denoting left or right view associated for modeling objects present in each frame, ii. operating the network to learn a latent encoding vector for each distinct object and register the position of said objects, iii. in an inference step, predicting the positions of each object by using a filter, iv. using the frame predicted at the previous time step as input for the network and the positions of the objects predicted in step iii) to render the estimated position of the objects at the next time step to predict the next frame.

La présente invention concerne la synthèse chimique de la cannalactone, une adaptation de cette synthèse conduisant à un marquage au deutérium de la cannalactone, ainsi que l'utilisation de la cannalactone marquée au deutérium pour effectuer le dosage de la cannalactone naturelle des exsudats ou tissus de la plante de chanvre.

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