Sorbonne Université

Provided is a method for identifying molecules and compounds involved in the modulation of lipid synthesis and uptake, wherein said molecule or compound blocks or activates SREBP maturation, comprising contacting cells with a molecule or compound to be tested and observing the presence or absence of domains in the endoplasmic reticulum membrane formed by cholesterol esters with cholesterol or, alternately, localizing SREBP proteins within the cell after said contacting, wherein the molecule or compound is identified as an inhibitor of SREBP maturation when ER domains form within the cell or, alternately, SREBP signal is localized more in the endoplasmic reticulum, whereas the molecule or compound is identified as an activator of SREBP maturation when ER domains are absent or, alternately, SREBP signal is localized more in the nucleus or when its target genes are elevated.

The present invention concerns a new method for screening the activity of a molecule involved in regulating organelle domains, as well as a new method for modulating organelle domain formation. It further concerns the use of the giant organelle vesicles for studying organelle domain formation or in a method for screening the activity of a molecule or combination of molecules involved in the modulation of organelle domains. The invention also concerns a screening platform for identifying domain-modulating molecules in organelles and the molecules or combination of molecules identified by the screening method of the invention for use in the prevention and/or the treatment of diseases, disorders, or deficiencies related to the protein regulation and/or lipid metabolism.

La présente invention concerne un matériau composite comprenant des particules hybrides (1) incorporées dans une matrice polymère thermoplastique, lesdites particules hybrides (1) étant formées de particules inorganiques fonctionnalisées par au moins une molécule (2) portant au moins une fonction ionique impliquée dans au moins une paire d'ions et/ou au moins une fonction électrostatique impliquée dans au moins un groupement électronégatif susceptible d'être engagé dans au moins une liaison hydrogène, ladite au moins une molécule (2) étant un organosilane, et au moins un contre-ion et/ou au moins un donneur/accepteur de liaisons hydrogène (3) portant au moins une double liaison C=C, la quantité de paires d'ions et/ou de groupements électronégatifs susceptibles d'être engagés dans la au moins une liaison hydrogène en surface des particules inorganiques étant comprise entre 0,5 et 20% mol par rapport à la quantité de précurseurs des particules inorganiques.

System, eyewear and method for improving future visual performance or future cognitive performance of the individual. The system comprises a device for irradiating light toward an eye of the individual. The system is configured for: • determining, at a first time, first visual performance or first cognitive performance of the individual, • determining values of parameters of a first light to be irradiated toward an eye of the individual according to the first visual performance or the first cognitive performance of the individual, • irradiating, between the first time and a second time, the first light toward the eye of the individual, • determining, at the second time, second visual performance or second cognitive performance of the individual, • irradiating, after the second time, a second light toward the eye of the individual, when the second visual performance is better than the first visual performance or the second cognitive performance is better than the first cognitive performance, a light dose irradiated by the second light being greater than a light dose irradiated by the first light.

The invention relates to a method of producing hydrocarbons from a subterranean formation via a production tubing (110) of a production well (100) located in the subterranean formation (1), comprising: - collecting hydrocarbons from one or more inlets of the production tubing; - injecting gas into the production tubing; - injecting a solution comprising a polysiloxane compound into the production tubing; - forming a hydrocarbon-based foam within the production tubing; - recovering the hydrocarbon-based foam from the production tubing.

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Zusammenfassung wird geladen …

Zusammenfassung wird geladen …

Zusammenfassung wird geladen …

Zusammenfassung wird geladen …