Consejo Superior de Investigaciones Científicas Patente

The present invention refers to a method and/or to a system configured to measure and/or verify the radiation dose received by a patient after particle therapy treatment.

The present invention provides a catecholamine-based membrane for use in the treatment of cancer, wherein the self-standing catecholamine-based membrane is obtainable by a process comprising the steps of: (a) cross-linking a catechol derivative with an amine selected from the group consisting of: a known aliphatic amine hydrocarbon of formula (II); and an aromatic amine of formula (IIbis), in a liquid medium, wherein both the catechol and the amine are soluble, at a pH comprised from 6.5 to 10, and under appropriate agitation to create a catecholamine membrane in the air/liquid interface in the absence of any support; and b) isolating the membrane resulting from step (a) from the air/liquid interface. <img class="EMIRef" id="92cf978d-a85c-4e3c-981c-8d480bec373c-ia01" />

The present invention relates to new tricyclic organic compounds of formula (I):having antiviral activity, stereoisomers and pharmaceutically acceptable salts thereof, their use as a medicament, especially an antiviral medicament, and a pharmaceutical composition comprising the same.

A single-channel apparatus (100) implementing a method for reducing noise in spectral estimations comprises an input signal port (111) for receiving an input signal (10) that contains both direct and reflected components. A calibration switch (112) alternates the signal path between a calibration load (118), which isolates the system for measuring internal noise, and the input signal (10) for signal acquisition. These signals are processed through a single receiver chain (119) into a digital signal processor (120) which implements noise-reduction by processing the calibration and signal acquisition measurements to compute the respective autocorrelation functions, their Fourier transforms and estimations of the power spectral densities, to compute a cleaned autocorrelation function, and deliver an output (330) as spectral estimations with reduced noise. This apparatus is configured to achieve accurate spectral analysis by leveraging self-calibration, simplifying design and improving sensitivity in different applications. For example, the DSP (120) can perform a reflectometry-specific process which uses the cleaned autocorrelation function to estimate a reflection coefficient.

The invention relates to a reversible light-regulated agonists compounds of formula (I), or a pharmaceutical salt thereof, wherein the meanings for the various substituents are as disclosed in the description. Further, the invention relates to its use as a medicament, particularly for the treatment of skin diseases, autoimmune diseases, cancer, disorders of calcium metabolism, neuromuscular disorders, and cardiovascular diseases by local and temporarily restricted activation of Vitamin D receptor. <img class="EMIRef" id="0901e7dd-0530-4cd0-a74e-eb3c9b175eda-ia01" />

Method for producing a metadata chip (8) of data modules (41), comprising the steps of preparing a sacrificial layer (2), a first structural layer (3) configured to allows light to pass through, a design layer (4) being capable of including bidimensional metadata information, having a high optical contrast, shaping the design layer (4) using a photolithography, engraving or etching technique, to define shape and dimensions of a data module (41), shaping a first cover (31) of the data modules (41), and removing the sacrificial layer (2) in order to produce metadata chips (8) not easily visible, containing metadata security information, for enhancing security.

The present invention refers to a cementitious composite characterized in that it exhibits thermoelectricity and radiative cooling properties, such that the Seebeck coefficient is >2000 µV/K and the solar reflectance is above 0.95, both values included, particularly, the cementitious composite comprises zeolite selected among Z4A, ZSM.5, MCM-21, MCM-22 and mixtures of them, preferably in a high proportion over 60% by weight.

The present invention relates to a peptide-bound boron cluster complex for use in boron neutron capture therapy (BNCT). The present invention covers a library of complexes where one or more icosahedral boron clusters, such as carboranes and metallacarboranes, are linked to peptides or hormone analogues that bind to receptors or antigens overexpressed in tumors.

Present invention refers to a triboelectric nanogenerator and manufacturing method thereof, comprising: an electrode having a composite material layer attached to the electrode; and a counter-electrode having a tribo-negative material layer attached to the counter-electrode, configured to contact the composite material layer by an external force; wherein the composite material layer comprises a tridimensional nanostructure of a first tribo-positive isolating material having a plurality of interconnected pores filled with a second tribo-positive isolating polymeric material.

The invention discloses a polypeptide with hyaluronidase activity from Purpureocillium sp, comprising the amino acid sequence in SEQ. ID. No. 1 or a variant thereof, a polynucleotide comprising said polypeptide, a recombinant vector, a host cell and a method to produce the polypeptide of SEQ. ID. No. 1 or a variant thereof and its use to produce a mixture of hyaluronan oligosaccharides.

The present invention discloses a device (1) for receiving an initial sequence (2) of polarized photons, modifying the polarization of each of said photons and performing measurements upon each of said photons according to an embodiment of the present invention. The device (1) comprises a beam splitter (3); two half-wave plates (4, 4'), two quarter-wave plates (5, 5'); two polarizer beam splitters (6, 6'), four single-photon detectors (7, 7', 7", 7‴), tagging means (8) connected to the single-photon detectors (7, 7', 7", 7‴) and rotating means (9) connected to the half-wave (4, 4') and quarter-wave plates (5, 5'). These elements are arranged and configured in such a way that the polarization of each photon comprised in the incoming light beam or initial sequence (2) of photons can be corrected before decoding. A system for transmitting a cryptographic key according to a Quantum Key Distribution, protocol with polarization correction and a method for correcting the polarization of each photon comprised in the sequence of photons used in the transmission of a cryptographic key according to a QKD protocol are also disclosed.

A method and system for testing triboelectric materials comprising: a first platform (2); a counter-electrode (5) arranged on the first platform to receive a piece of a first triboelectric material; a force measurement means to measure force at the first platform; a piston (11); a second platform (12) at one end of the piston; an electrode (13) arranged at the second platform to receive a piece of a second triboelectric material; a drive system (15) to vertically move the piston to a position with contact between the two triboelectric materials at a certain level of force and frequency; and measuring means to measure an output signal as result of the contact between the triboelectric materials.

The present invention refers to benzothiazolium salts of formula (I) and its use in therapy. More particularly, they are useful in the treatment and/or prevention of parasitic infections. The present invention also relates to pharmaceutical composition comprising them.

The present invention refers to AG5 compound, and compositions or combined preparations comprising said compound, for use in the treatment and/or prevention of a fatty liver disease or disorder.

The vast majority of prokaryotic microorganisms remains uncultured and are not abundant enough to be effectively studied using metagenomic sequencing methods. Here, we present a novel PCR-free target capture sequencing approach that enables targeting specific genes or functions with full phylogenetic coverage in a single sequencing experiment, proving also a higher sensitivity and precision than regular shotgun and amplicon-based approaches.

The present invention provides a stimulation and recording neural probe (100) at least comprising: a substrate (10); a stimulation and recording array (12), said stimulation and recording array (12) including at least one single-layer or double-layer solution-gated graphene field effect transistor (SG-GFET) (14) for recording brain signals of a patient, and at least one electrode (16) for applying electrical stimulation to a brain tissue and/or recording brain signals of the patient; and metal tracks (18, 20) for the at least one electrode (16) and the at least one single-layer or double layer SG-GFET (14), encapsulated in respective first and second encapsulation layers (22, 24). The invention further provides a method of manufacturing a stimulation and recording neural probe, such as the neural probe described above. Still further, the invention provides closed-loop system (200) for brain stimulation and recording comprising a control unit (202) and a stimulation unit (204), the stimulation unit (204) comprising at least one neural probe as described above.

The present invention relates to a genetic construct that allows overexpression in plants of the Arabidopsis HOP3 protein (AtHOP3) under the specific Arabidopsis BIP3 promoter (AtBIP3 promoter or pAtBIP3) under high salt conditions. The present invention also relates to transgenic plants, or parts thereof, comprising the genetic construct of the present invention, and to the use of these plants in crops subjected to environmental stress or any other condition that courses with ER stress.

The present invention refers to a combination of enzymes that presents antimicrobial features. Specifically, the combination of the invention comprises an endolysin and a glucose oxidase. Surprisingly, the combination of the invention presents a synergistic antimicrobial effect that is useful for the control of food borne pathogens, such as Listeria monocytogenes.

A surface emission random laser and a manufacturing method thereof, wherein the random laser comprises: a semiconductor die (1) comprising a plurality of semiconductor layers; two or more electrodes (2), attached to the semiconductor die (1) for current injection; an optically active layer (3) placed between two semiconductor layers to produce optical amplification as a response to the current injection; two planar confinement layers (4), arranged over and under the optically active layer (3) configured for light confinement; and one or more scattering elements (5), being holes or grooves drilled in the semiconductor die (1) and extending at least to reach the optically active layer (3) and defining scattering rough surfaces (7) divided into: a proximal scattering surface (8) for optical feedback; and a distal scattering surface (9) for light extraction (6).

The invention refers to a gripper for the separation of layers of a deformable material, the layers being stacked on a surface, comprising a foot (10) configured to be fastened to a robot, two arms for the grabbing of the layers and a motor (20) for the movement of the arms, wherein a first arm comprises a shaft (3) where a plurality of rolls (1, 2) is located, and a second arm comprises at least one finger (4) which further comprises a tip (6) with a longitudinal configuration, a housing (5), where one end of the tip (6) is fixed, and a spring (14), located within the housing (5) that provides longitudinal movement to the tip (6), wherein, one of the rolls (1, 2) comprises protuberances (13) on the surface to provide a friction surface, and the second arm is configured to move towards the first arm.

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The invention relates to a device for the detection of gamma rays to be used primarily in a PET scanner, based on a scintillator heterostructure combining the high stopping power of scintillators commonly used in PET scanners (such as L(Y)SO, BGO, etc.) and fast scintillators based on polymers loaded with fast emitting dyes or nanocrystals, or thin layers of nanocrystals or multiple quantum well structures. While the metascintillator block is read out in the monolithic or semi-monolithic arrangement, the fast scintillator is segmented so that it is read out by less photodetectors. The particular arrangement of this detector module allows combining all the important features of a high-performance Time-of-Flight PET (TOFPET) detector module, i.e. a high photoelectric detection efficiency for the gamma rays, a precise 3D information (including the depth of interaction DOI) of the gamma ray conversion in the module, good energy resolution and superior timing resolution.

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