Max-Planck-Gesellschaft

A method for training a 3D occupancy prediction network , said method comprising a. Obtaining (S1) a plurality of input images (Ik) of a scene, b. Extracting (S3), a relative depth information for 3D points of a target image (Itarget), c. Obtaining (S4), an absolute depth information (Dtarget) of said target image (Itarget), d. Obtaining (S5) a reconstructed target image using said absolute depth information (Dtarget), e. Obtaining (S6), semantic information of pixels of said target image (Itarget) and semantic information of pixels of said reconstructed target image (Îtarget), f. Selecting (S7) pixels (u') of said target image whose semantic information is the same in said target image (Itarget) and in said reconstructed target image (Îtarget), g. optimizing (S8) a semantic loss ( L sem − refine <img class="EMIRef" id="6f4b85ad-6654-4121-9a00-e379a7f9b3e4-ia01" /> ) function as a binary cross entropy applied on patches ( S i ′ u i ′ <img class="EMIRef" id="6f4b85ad-6654-4121-9a00-e379a7f9b3e4-ia02" /> ) and reconstructed patches ( S ^ i ′ u i ′ <img class="EMIRef" id="6f4b85ad-6654-4121-9a00-e379a7f9b3e4-ia03" /> ) of said selected pixels, h. optimizing (S9) a depth supervision loss ( L depth <img class="EMIRef" id="6f4b85ad-6654-4121-9a00-e379a7f9b3e4-ia04" /> ) function

Disclosed is an electrostatic gliding transducer (100) for converting energy between an electrostatic energy form and a mechanical energy form, which comprises a stator (102) and a glider (112). The stator (102) comprising a first electrode (104) on a first solid dielectric element (106). The glider (112) comprises a second electrode (114) on a second solid dielectric element (116). The first and second dielectric element (106, 116) are arranged between the two electrodes (104, 114) and spaced apart from each other with a clearance (126) filled with a dielectric liquid (110) providing for a hydrodynamic lubrication. The electrostatic gliding transducer (100) is adapted for a moving of the glider (112) relative to the stator (102) along a direction of movement with the second dielectric element (116) gliding hydrodynamically on the dielectric liquid (110) along the first dielectric element (106) in an activated state of the transducer (100).

The present invention pertains to the fields of antibody technology, medicine, pharmacology, infection biology, and medical diagnostics. More specifically, the present disclosure provides a VHH antibody that neutralizes herpes simplex viruses HSV-1 and HSV-2 by blocking the pre-fusion state of the gB fusion protein, as well as methods for using this VHH against HSV infections.

Systems and methods are provided for reconstructing 3D hair geometry. In some examples, the method includes for each synthetic hairstyle of a plurality of synthetic hairstyles, generating a set of digital 3D hair strands and a corresponding synthetic image of the respective synthetic hairstyle; generating a structured 2D representation for the set of hair strands of the respective synthetic hairstyle, the structured 2D representation including a density map and a scalp or skin texture; sampling a plurality of texels from the scalp or skin texture by using the density map; and training a diffusion model based on the structured 2D representation and the corresponding synthetic image to generate a trained diffusion model.

The present invention relates to a localized magnetization precession of a chiral Néel domain wall (DW) at a distinct resonance frequency of 450 MHz that is far below the FMR mode (9.5 GHz). The Invention further relates to the modification of the DW motion upon the excitation of this DW resonance. In particular, the stimulation of the DW resonance in a static transverse magnetic field leads to self-propulsion of the DW without the need of a direct electrical current. Moreover, the stimulation in a static longitudinal magnetic field, which leads to a current-triggered sustained propulsion of DWs, reveals a significant enhancement in efficiencies for both a symmetric, currentinduced DWM and SOT induced magnetization switching.

A spectroscopic measuring apparatus 100 for measuring a spectral response of a sample 1 comprises a probe light source device 11 irradiating the sample with a probe light pulse 2 with a probe pulse duration, wherein an interaction of the probe light pulse 2 with the sample 1 results in a free induction decay light field 3 with a free induction decay duration greater than the probe pulse duration; an amplifier device amplifying the free induction decay light field 3; and a detector device 30 providing the spectral response of the sample by temporally resolved detecting the free induction decay light field 3, wherein the amplifier device is an optical parametric amplification (OPA) device 20 with a pump light source device 21 repeatedly creating a pump light pulse 5 having a pump pulse duration shorter than the free induction decay duration, and further including an optically non-linear medium 22, and the OPA device 20 is arranged for an optical parametric amplification of the free induction decay light field 3 by scanning the free induction decay light field 3 with the pump light pulse 5 repeatedly provided with a varying amplification delay relative to the free induction decay light field 3, and the detector device 30 includes a sampling light source device 31 repeatedly creating a sampling light pulse 4 with a sampling pulse duration shorter than the free induction decay duration, wherein the detector device 30 is arranged for time domain sampling the free induction decay light field 3 by scanning the free induction decay light field 3 with the sampling light pulse 4 repeatedly created with a varying sampling delay relative to the free induction decay light field 3, said sampling light pulse being provided synchronously with the pump light pulse 5. Furthermore, a spectroscopic measuring method for measuring a spectral response of a sample is described.

Systems and methods are provided for estimating subject pose and shape. In some examples, the method includes generating, by an image encoder, a structured representation for an image; mapping, by a prompt encoder, a plurality of types of prompts associated with the image to a plurality of prompt tokens; and estimating, by using a transformer-based computing model, a set of subject parameters based at least in part on the structured representation and the plurality of prompt tokens. In some examples, the plurality of types of prompts includes a first type of prompts having a first modality and a second type of prompts having a second modality different from the first modality.

The invention herein disclosed refers to a method for preparation of glycerol nanocapsules (GNCs), adapted as an additive in a hydrophobic lubricant for improving lubricity in a tribological system, further to a glycerol nanocapsule (GNC) and finally to the respective use. The method comprises the steps of providing a continuous phase comprising at least a polyalphaolefin (PAO) and a dispersed phase comprising at least glycerol (GLY), of - mixing the continuous phase and the dispersed phase and performing high-pressure homogenization with a microfluidizer resulting in a minielmulsion comprising glycerol nanodroplets (GNPs). Further, adding a diisocyanate crosslinking agent (TDI) to the miniemulsion is comprised, leading to a polymerization reaction of the diisocyanate crosslinking agent (TDI) and glycerol (GLY) at the interfaces of the glycerol nanodroplets (GNPs) dispersed in the polyalphaolefin (PAO), resulting in formation of crosslinked glycerol-based polyurethan shells encapsulating a core of unreacted glycerol (GLY). Thereby glycerol nanocapsules (GNCs) are obtained, comprising a core of unreacted glycerol (GLY) encapsulated in a crosslinked glycerol-based polyurethan shell.

The present invention relates to a therapeutic nucleic acid molecule comprising or consisting of an open reading frame comprising (i) a part of a gene, wherein the part comprises (a) at least one intron and the flanking exons of the gene, (b) at least two exons of the gene, wherein the first exon encodes the 5'UTR or the last exon encodes the 3'UTR, (c) at least one exon of the gene preceded by an exogenous 5'UTR or followed by an exogenous 3'UTR, or (d) at least one exon of the gene, wherein the gene is associated with a disease in humans or is useful for treating a disease in humans, wherein the disease can be treated by the expression of the gene itself or one of its functional or sequence paralogs; and (ii) inserted within the part of a gene according to (i) a nucleic acid sequence encoding a self-cleavable ribozyme, wherein (a') in (a) the nucleic acid sequence encoding a self-cleavable ribozyme is inserted into the intron, (b') in (b) the nucleic acid sequence encoding a self-cleavable ribozyme is inserted into the 5' or 3'UTR, (c') in (c) the nucleic acid sequence encoding a self-cleavable ribozyme is inserted into the exogenous 5' or 3'UTR, and (d') in (d) the nucleic acid sequence encoding a self-cleavable ribozyme is inserted into at least one exon.

It has been surprisingly found that human oocytes lack the important spindle-associated protein KIFC1/HSET. The application describes a method stabilising the human spindle with KIFC1/HSET. Specifically, the method relates to introducing (i) KIFC1/HSET protein or (ii) mRNA encoding KIFC1/HSET into a human oocyte. Furthermore, the application relates to a non-naturally occurring human oocyte, wherein a (i) KIFC1/HSET protein or (ii) KIFC1/HSET mRNA has been introduced into a naturally occurring human oocyte thereby obtaining the non-naturally occurring oocyte. Additionally, the application relates to a (i) KIFC1/HSET protein or (ii) mRNA encoding the KIFC1/HSET for use in a method of lowering the probability of having a disorganized and/or a multipolar spindle during mitosis in a human zygote by introducing the (i) KIFC1/HSET protein or (ii) mRNA encoding the KIFC1/HSET into the human zygote. Moreover, the application discloses a complex comprising (i) a KIFC1/HSET protein and (ii) a human meiotic spindle or a human mitotic spindle, wherein the KIFC1/HSET protein has been introduced into a human oocyte or zygote.