Max-Planck-Gesellschaft

A spectroscopic measuring apparatus 100 for measuring a spectral response of a sample 1 comprises a probe light source device 11 irradiating the sample with a probe light pulse 2 with a probe pulse duration, wherein an interaction of the probe light pulse 2 with the sample 1 results in a free induction decay light field 3 with a free induction decay duration greater than the probe pulse duration; an amplifier device amplifying the free induction decay light field 3; and a detector device 30 providing the spectral response of the sample by temporally resolved detecting the free induction decay light field 3, wherein the amplifier device is an optical parametric amplification (OPA) device 20 with a pump light source device 21 repeatedly creating a pump light pulse 5 having a pump pulse duration shorter than the free induction decay duration, and further including an optically non-linear medium 22, and the OPA device 20 is arranged for an optical parametric amplification of the free induction decay light field 3 by scanning the free induction decay light field 3 with the pump light pulse 5 repeatedly provided with a varying amplification delay relative to the free induction decay light field 3, and the detector device 30 includes a sampling light source device 31 repeatedly creating a sampling light pulse 4 with a sampling pulse duration shorter than the free induction decay duration, wherein the detector device 30 is arranged for time domain sampling the free induction decay light field 3 by scanning the free induction decay light field 3 with the sampling light pulse 4 repeatedly created with a varying sampling delay relative to the free induction decay light field 3, said sampling light pulse being provided synchronously with the pump light pulse 5. Furthermore, a spectroscopic measuring method for measuring a spectral response of a sample is described.

The present invention relates to a localized magnetization precession of a chiral Néel domain wall (DW) at a distinct resonance frequency of 450 MHz that is far below the FMR mode (9.5 GHz). The Invention further relates to the modification of the DW motion upon the excitation of this DW resonance. In particular, the stimulation of the DW resonance in a static transverse magnetic field leads to self-propulsion of the DW without the need of a direct electrical current. Moreover, the stimulation in a static longitudinal magnetic field, which leads to a current-triggered sustained propulsion of DWs, reveals a significant enhancement in efficiencies for both a symmetric, currentinduced DWM and SOT induced magnetization switching.

Systems and methods are provided for estimating subject pose and shape. In some examples, the method includes generating, by an image encoder, a structured representation for an image; mapping, by a prompt encoder, a plurality of types of prompts associated with the image to a plurality of prompt tokens; and estimating, by using a transformer-based computing model, a set of subject parameters based at least in part on the structured representation and the plurality of prompt tokens. In some examples, the plurality of types of prompts includes a first type of prompts having a first modality and a second type of prompts having a second modality different from the first modality.

The invention herein disclosed refers to a method for preparation of glycerol nanocapsules (GNCs), adapted as an additive in a hydrophobic lubricant for improving lubricity in a tribological system, further to a glycerol nanocapsule (GNC) and finally to the respective use. The method comprises the steps of providing a continuous phase comprising at least a polyalphaolefin (PAO) and a dispersed phase comprising at least glycerol (GLY), of - mixing the continuous phase and the dispersed phase and performing high-pressure homogenization with a microfluidizer resulting in a minielmulsion comprising glycerol nanodroplets (GNPs). Further, adding a diisocyanate crosslinking agent (TDI) to the miniemulsion is comprised, leading to a polymerization reaction of the diisocyanate crosslinking agent (TDI) and glycerol (GLY) at the interfaces of the glycerol nanodroplets (GNPs) dispersed in the polyalphaolefin (PAO), resulting in formation of crosslinked glycerol-based polyurethan shells encapsulating a core of unreacted glycerol (GLY). Thereby glycerol nanocapsules (GNCs) are obtained, comprising a core of unreacted glycerol (GLY) encapsulated in a crosslinked glycerol-based polyurethan shell.

The present invention relates to a therapeutic nucleic acid molecule comprising or consisting of an open reading frame comprising (i) a part of a gene, wherein the part comprises (a) at least one intron and the flanking exons of the gene, (b) at least two exons of the gene, wherein the first exon encodes the 5'UTR or the last exon encodes the 3'UTR, (c) at least one exon of the gene preceded by an exogenous 5'UTR or followed by an exogenous 3'UTR, or (d) at least one exon of the gene, wherein the gene is associated with a disease in humans or is useful for treating a disease in humans, wherein the disease can be treated by the expression of the gene itself or one of its functional or sequence paralogs; and (ii) inserted within the part of a gene according to (i) a nucleic acid sequence encoding a self-cleavable ribozyme, wherein (a') in (a) the nucleic acid sequence encoding a self-cleavable ribozyme is inserted into the intron, (b') in (b) the nucleic acid sequence encoding a self-cleavable ribozyme is inserted into the 5' or 3'UTR, (c') in (c) the nucleic acid sequence encoding a self-cleavable ribozyme is inserted into the exogenous 5' or 3'UTR, and (d') in (d) the nucleic acid sequence encoding a self-cleavable ribozyme is inserted into at least one exon.

The present disclosure relates to a system for performing a quantum manipulation protocol, e.g., a quantum computing algorithm, the system comprising: a trapping laser system for trapping neutral atoms in an optical trap array inside a vacuum chamber operated at a trapping wavelength λ<tr>, wherein each neutral atom comprises a ground state |<1>S<o>>, a first metastable excited state |<3>P<o>> and a second metastable excited state |<3>P<2>>. The system further comprises a state manipulation laser system for generating laser radiation for coupling, via a phase-coherent multi-photon transition, the ground state |<1>S<o>> to the first metastable excited state |<3>P<o>> and / or to the second metastable excited state |<3>P<2>> as well as a magnetic field system for generating a magnetic field B<ext> at a location of the optical trap array inducing a Zeeman splitting for magnetic substates of the second metastable excited state |<3>P<2>>. The system further comprises a control system for controlling the laser radiation generated by the laser system to coherently modify a quantum state of the plurality of neutral atoms based on the quantum manipulation protocol and a a quantum state readout system for determining the quantum state of at least a subset of the plurality of neural atoms based on the quantum manipulation protocol. According to some aspects, a direction of the magnetic field B<ext> with respect to a polarization direction of the optical trap array is selected such as to render the optical trap array operated at the trapping wavelength λ<tr> a magic-wavelength optical trap for the second metastable excited state |<3>P<2>> and the first metastable excited state |<3>P<o>> and / or for the second metastable excited state |<3>P<2>> and the ground state |<1>S<o>> or both.

Provided is a microfluidic device with a front end comprising a tip with an opening for providing a hydrodynamic flow confinement. The device includes a first inflow channel adapted to provide a microfluidic flow to the tip, an outflow channel adapted to collect at least partially the microfluidic flow provided via the first inflow channel at the tip, and a second inflow channel adapted to provide a microfluidic flow to the tip. The device is characterized in that at the front end the first inflow channel extends within the outflow channel and the outflow channel extends within the second inflow channel.

The present invention relates to process for fractionating polymeric material, comprising the steps of: providing a solution of polymeric material with a molecular weight distribution, having an average molecular weight, in a solvent or a solvent mixture, charging the solution into a filter unit of a fractionation system, wherein the filter unit comprises a filter bed, inducing a phase separation in the solution within the filter unit to form a dispersion, wherein the polymeric material is separated into a separated fraction and a non-separated fraction, wherein the polymeric material in the separated fraction differs from the polymeric material in the non-separated fraction with regard to the molecular weight distribution and/or the average molecular weight of the molecular weight distribution, and applying a force to the dispersion, causing it to pass through the filter bed from a first side to a second side, capturing the separated fraction, in particular a molecular weight fraction, in the filter bed.

The present invention relates to self-assembling peptides consisting of at least 6 amino acids and containing the amino acid sequence X1-A4-A5-A6-X2. Said peptides self-assemble into fibrils especially under physiological conditions in an aqueous dispersion phase thereby forming a hydrogel and are thus particularly useful for forming a hydrogel composition.

The present invention relates to a pharmaceutical composition comprising an agent for enhancing peroxisomes for use for treatment of a condition associated with alpha-1-antitrypsin deficiency (AATD).