Max-Planck-Gesellschaft Patente

The present invention provides a alcohol oxidoreductase polypeptide converting 5-hydroxymethyl-2-furoic acid (HMFA) to 5-formyl-2-furoic acid (FFA) with a Km value of less than 15 mM selected from the group consisting of a polypeptide having the amino acid sequence shown in SEQ ID NO: 1, wherein (a) in said polypeptide amino acids at positions F412, F459 and W561 are V, W or R and A, respectively; or (d) in said polypeptide amino acids at positions F412, L560 and W561 are V, R or W and A, respectively; or (g) in said polypeptide amino acids at positions F412, L455 and W561 are V, W or R and A, respectively; preferably in the polypeptide (a) or (d) amino acids at positions F412, F459, L560 and W561 are V, W or R, R or W and A, respectively and this polypeptide converts FFA to 2,5 furandicarboxylic acid (FDCA).

The invention relates to a device (100) for being used with a hydrogen storage container (50) and/or for controlling a gaseous phase of hydrogen (6b) being stored in the storage container (50), comprising: - adsorption means (10) comprising adsorbent material (13), the adsorbent material (13) being configured to adsorb hydrogen; and - temperature controlling means (20) configured to control a temperature of the adsorption means (10) and/or the adsorbent material (13). Further, the invention relates to a storage system (200) for hydrogen, and a method for controlling a gaseous phase of hydrogen (6b) being stored in a storage volume for hydrogen.

The present invention relates to a method for filling a target liquid hydrogen storage vessel (200), the method comprising:- providing a mixture (30) of liquid hydrogen (10) and adsorbent material (20) in a preparatory liquid hydrogen storage vessel (100), the adsorbent material (20) being configured to adsorb hydrogen; and- conveying, at least in part, the mixture (30) of liquid hydrogen (10) and adsorbent material (20) from the preparatory liquid hydrogen storage vessel (100) to the target liquid hydrogen storage vessel (200).Further, the present invention relates to a hydrogen storage system (500).

The present invention relates to a method of analyzing multiple samples, said method using a system comprising a plurality of chromatographic columns connected to one mass spectrometer, said method comprising loading different samples onto different chromatographic columns at different times, followed by elution, wherein the shortest time that elapses between successive starts of elution from said columns within said system min(delta t) is shorter than the shortest time required for elution min(t(elution)).

The present invention concerns a method for cocultivation of microorganisms in particular for producing bacterial cellulose and biomass including the steps of: (a) Providing a liquid culture of at least a first microorganism which is an oxygen producing microorganism; (b) Providing a liquid culture of at least a second microorganism which is capable of producing bacterial cellulose; (c) Providing a dispersant; (d) Preparing a mixture of the liquid cultures of step (a), step (b) and of the dispersant provided in step (c); (e) coculturing the mixture obtained in step (d) to generate an engineered living material, as well as a bioreactor comprising the engineered living material. In another aspect, the present invention concerns an engineered living material comprising a first microorganism which is an oxygen producing microorganism, and a second microorganism which is capable of producing bacterial cellulose, and a dispersant. Further, the present invention concerns an engineered living material comprising a first microorganism which is an oxygen producing microorganism, a second microorganism which is capable of producing bacterial cellulose, and a dispersant.

Systems (100) and methods are provided for motion generation. In some examples, a method includes extracting a plurality of motion segments (102), each motion segment including a series of frames, training a diffusion model based on each motion segment of the plurality of motion segments to generate a base motor model (104), incorporating a control adaptor (106) into one or more transformer blocks of the base motor model (104), and training the control adaptor (106) by using the control input to obtain a taskspecific adapted model.

The present invention relates to a method for identifying the linkages between nucleosomes by DNA linkers in a cluster of nucleosomes and to a method for identifying the path of DNA along nucleosomes. The invention further relates to a method for determining the nucleosome distance pattern of a patch of chromatin and to a method for identifying the genomic position of a patch of chromatin. Furthermore, the invention relates to a method for determining the nucleotide sequence of DNA. Furthermore, the invention relates to a computer program, a data processing system, and a computer-readable medium for carrying out the steps of the methods according to the invention.

The present invention is directed towards catalysts comprising iron-containing particles, as well as methods of completing hydrodeoxygenation reactions utilising such catalysts. In particular, a method employing such catalysts to complete the hydrodeoxygenation of esters is claimed. The catalysts and methods of the present invention improve upon the disadvantages associated with literature hydrodeoxygenation reactions and in particular, allow hydrodeoxygenation reactions under mild conditions with good substrate scope, high yields and high selectivity.

A method for training a 3D occupancy prediction network , said method comprising a. Obtaining (S1) a plurality of input images (Ik) of a scene, b. Extracting (S3), a relative depth information for 3D points of a target image (Itarget), c. Obtaining (S4), an absolute depth information (Dtarget) of said target image (Itarget), d. Obtaining (S5) a reconstructed target image using said absolute depth information (Dtarget), e. Obtaining (S6), semantic information of pixels of said target image (Itarget) and semantic information of pixels of said reconstructed target image (Îtarget), f. Selecting (S7) pixels (u') of said target image whose semantic information is the same in said target image (Itarget) and in said reconstructed target image (Îtarget), g. optimizing (S8) a semantic loss ( L sem − refine <img class="EMIRef" id="6f4b85ad-6654-4121-9a00-e379a7f9b3e4-ia01" /> ) function as a binary cross entropy applied on patches ( S i ′ u i ′ <img class="EMIRef" id="6f4b85ad-6654-4121-9a00-e379a7f9b3e4-ia02" /> ) and reconstructed patches ( S ^ i ′ u i ′ <img class="EMIRef" id="6f4b85ad-6654-4121-9a00-e379a7f9b3e4-ia03" /> ) of said selected pixels, h. optimizing (S9) a depth supervision loss ( L depth <img class="EMIRef" id="6f4b85ad-6654-4121-9a00-e379a7f9b3e4-ia04" /> ) function

Disclosed is an electrostatic gliding transducer (100) for converting energy between an electrostatic energy form and a mechanical energy form, which comprises a stator (102) and a glider (112). The stator (102) comprising a first electrode (104) on a first solid dielectric element (106). The glider (112) comprises a second electrode (114) on a second solid dielectric element (116). The first and second dielectric element (106, 116) are arranged between the two electrodes (104, 114) and spaced apart from each other with a clearance (126) filled with a dielectric liquid (110) providing for a hydrodynamic lubrication. The electrostatic gliding transducer (100) is adapted for a moving of the glider (112) relative to the stator (102) along a direction of movement with the second dielectric element (116) gliding hydrodynamically on the dielectric liquid (110) along the first dielectric element (106) in an activated state of the transducer (100).

The present invention pertains to the fields of antibody technology, medicine, pharmacology, infection biology, and medical diagnostics. More specifically, the present disclosure provides a VHH antibody that neutralizes herpes simplex viruses HSV-1 and HSV-2 by blocking the pre-fusion state of the gB fusion protein, as well as methods for using this VHH against HSV infections.

Systems and methods are provided for reconstructing 3D hair geometry. In some examples, the method includes for each synthetic hairstyle of a plurality of synthetic hairstyles, generating a set of digital 3D hair strands and a corresponding synthetic image of the respective synthetic hairstyle; generating a structured 2D representation for the set of hair strands of the respective synthetic hairstyle, the structured 2D representation including a density map and a scalp or skin texture; sampling a plurality of texels from the scalp or skin texture by using the density map; and training a diffusion model based on the structured 2D representation and the corresponding synthetic image to generate a trained diffusion model.

The present invention relates to a localized magnetization precession of a chiral Néel domain wall (DW) at a distinct resonance frequency of 450 MHz that is far below the FMR mode (9.5 GHz). The Invention further relates to the modification of the DW motion upon the excitation of this DW resonance. In particular, the stimulation of the DW resonance in a static transverse magnetic field leads to self-propulsion of the DW without the need of a direct electrical current. Moreover, the stimulation in a static longitudinal magnetic field, which leads to a current-triggered sustained propulsion of DWs, reveals a significant enhancement in efficiencies for both a symmetric, currentinduced DWM and SOT induced magnetization switching.

A spectroscopic measuring apparatus 100 for measuring a spectral response of a sample 1 comprises a probe light source device 11 irradiating the sample with a probe light pulse 2 with a probe pulse duration, wherein an interaction of the probe light pulse 2 with the sample 1 results in a free induction decay light field 3 with a free induction decay duration greater than the probe pulse duration; an amplifier device amplifying the free induction decay light field 3; and a detector device 30 providing the spectral response of the sample by temporally resolved detecting the free induction decay light field 3, wherein the amplifier device is an optical parametric amplification (OPA) device 20 with a pump light source device 21 repeatedly creating a pump light pulse 5 having a pump pulse duration shorter than the free induction decay duration, and further including an optically non-linear medium 22, and the OPA device 20 is arranged for an optical parametric amplification of the free induction decay light field 3 by scanning the free induction decay light field 3 with the pump light pulse 5 repeatedly provided with a varying amplification delay relative to the free induction decay light field 3, and the detector device 30 includes a sampling light source device 31 repeatedly creating a sampling light pulse 4 with a sampling pulse duration shorter than the free induction decay duration, wherein the detector device 30 is arranged for time domain sampling the free induction decay light field 3 by scanning the free induction decay light field 3 with the sampling light pulse 4 repeatedly created with a varying sampling delay relative to the free induction decay light field 3, said sampling light pulse being provided synchronously with the pump light pulse 5. Furthermore, a spectroscopic measuring method for measuring a spectral response of a sample is described.

Systems and methods are provided for estimating subject pose and shape. In some examples, the method includes generating, by an image encoder, a structured representation for an image; mapping, by a prompt encoder, a plurality of types of prompts associated with the image to a plurality of prompt tokens; and estimating, by using a transformer-based computing model, a set of subject parameters based at least in part on the structured representation and the plurality of prompt tokens. In some examples, the plurality of types of prompts includes a first type of prompts having a first modality and a second type of prompts having a second modality different from the first modality.

The invention herein disclosed refers to a method for preparation of glycerol nanocapsules (GNCs), adapted as an additive in a hydrophobic lubricant for improving lubricity in a tribological system, further to a glycerol nanocapsule (GNC) and finally to the respective use. The method comprises the steps of providing a continuous phase comprising at least a polyalphaolefin (PAO) and a dispersed phase comprising at least glycerol (GLY), of - mixing the continuous phase and the dispersed phase and performing high-pressure homogenization with a microfluidizer resulting in a minielmulsion comprising glycerol nanodroplets (GNPs). Further, adding a diisocyanate crosslinking agent (TDI) to the miniemulsion is comprised, leading to a polymerization reaction of the diisocyanate crosslinking agent (TDI) and glycerol (GLY) at the interfaces of the glycerol nanodroplets (GNPs) dispersed in the polyalphaolefin (PAO), resulting in formation of crosslinked glycerol-based polyurethan shells encapsulating a core of unreacted glycerol (GLY). Thereby glycerol nanocapsules (GNCs) are obtained, comprising a core of unreacted glycerol (GLY) encapsulated in a crosslinked glycerol-based polyurethan shell.

The present invention relates to a therapeutic nucleic acid molecule comprising or consisting of an open reading frame comprising (i) a part of a gene, wherein the part comprises (a) at least one intron and the flanking exons of the gene, (b) at least two exons of the gene, wherein the first exon encodes the 5'UTR or the last exon encodes the 3'UTR, (c) at least one exon of the gene preceded by an exogenous 5'UTR or followed by an exogenous 3'UTR, or (d) at least one exon of the gene, wherein the gene is associated with a disease in humans or is useful for treating a disease in humans, wherein the disease can be treated by the expression of the gene itself or one of its functional or sequence paralogs; and (ii) inserted within the part of a gene according to (i) a nucleic acid sequence encoding a self-cleavable ribozyme, wherein (a') in (a) the nucleic acid sequence encoding a self-cleavable ribozyme is inserted into the intron, (b') in (b) the nucleic acid sequence encoding a self-cleavable ribozyme is inserted into the 5' or 3'UTR, (c') in (c) the nucleic acid sequence encoding a self-cleavable ribozyme is inserted into the exogenous 5' or 3'UTR, and (d') in (d) the nucleic acid sequence encoding a self-cleavable ribozyme is inserted into at least one exon.

It has been surprisingly found that human oocytes lack the important spindle-associated protein KIFC1/HSET. The application describes a method stabilising the human spindle with KIFC1/HSET. Specifically, the method relates to introducing (i) KIFC1/HSET protein or (ii) mRNA encoding KIFC1/HSET into a human oocyte. Furthermore, the application relates to a non-naturally occurring human oocyte, wherein a (i) KIFC1/HSET protein or (ii) KIFC1/HSET mRNA has been introduced into a naturally occurring human oocyte thereby obtaining the non-naturally occurring oocyte. Additionally, the application relates to a (i) KIFC1/HSET protein or (ii) mRNA encoding the KIFC1/HSET for use in a method of lowering the probability of having a disorganized and/or a multipolar spindle during mitosis in a human zygote by introducing the (i) KIFC1/HSET protein or (ii) mRNA encoding the KIFC1/HSET into the human zygote. Moreover, the application discloses a complex comprising (i) a KIFC1/HSET protein and (ii) a human meiotic spindle or a human mitotic spindle, wherein the KIFC1/HSET protein has been introduced into a human oocyte or zygote.

The present disclosure relates to a system for performing a quantum manipulation protocol, e.g., a quantum computing algorithm, the system comprising: a trapping laser system for trapping neutral atoms in an optical trap array inside a vacuum chamber operated at a trapping wavelength λ<tr>, wherein each neutral atom comprises a ground state |<1>S<o>>, a first metastable excited state |<3>P<o>> and a second metastable excited state |<3>P<2>>. The system further comprises a state manipulation laser system for generating laser radiation for coupling, via a phase-coherent multi-photon transition, the ground state |<1>S<o>> to the first metastable excited state |<3>P<o>> and / or to the second metastable excited state |<3>P<2>> as well as a magnetic field system for generating a magnetic field B<ext> at a location of the optical trap array inducing a Zeeman splitting for magnetic substates of the second metastable excited state |<3>P<2>>. The system further comprises a control system for controlling the laser radiation generated by the laser system to coherently modify a quantum state of the plurality of neutral atoms based on the quantum manipulation protocol and a a quantum state readout system for determining the quantum state of at least a subset of the plurality of neural atoms based on the quantum manipulation protocol. According to some aspects, a direction of the magnetic field B<ext> with respect to a polarization direction of the optical trap array is selected such as to render the optical trap array operated at the trapping wavelength λ<tr> a magic-wavelength optical trap for the second metastable excited state |<3>P<2>> and the first metastable excited state |<3>P<o>> and / or for the second metastable excited state |<3>P<2>> and the ground state |<1>S<o>> or both.

Provided is a microfluidic device with a front end comprising a tip with an opening for providing a hydrodynamic flow confinement. The device includes a first inflow channel adapted to provide a microfluidic flow to the tip, an outflow channel adapted to collect at least partially the microfluidic flow provided via the first inflow channel at the tip, and a second inflow channel adapted to provide a microfluidic flow to the tip. The device is characterized in that at the front end the first inflow channel extends within the outflow channel and the outflow channel extends within the second inflow channel.

The present invention relates to process for fractionating polymeric material, comprising the steps of: providing a solution of polymeric material with a molecular weight distribution, having an average molecular weight, in a solvent or a solvent mixture, charging the solution into a filter unit of a fractionation system, wherein the filter unit comprises a filter bed, inducing a phase separation in the solution within the filter unit to form a dispersion, wherein the polymeric material is separated into a separated fraction and a non-separated fraction, wherein the polymeric material in the separated fraction differs from the polymeric material in the non-separated fraction with regard to the molecular weight distribution and/or the average molecular weight of the molecular weight distribution, and applying a force to the dispersion, causing it to pass through the filter bed from a first side to a second side, capturing the separated fraction, in particular a molecular weight fraction, in the filter bed.

The present invention relates to self-assembling peptides consisting of at least 6 amino acids and containing the amino acid sequence X1-A4-A5-A6-X2. Said peptides self-assemble into fibrils especially under physiological conditions in an aqueous dispersion phase thereby forming a hydrogel and are thus particularly useful for forming a hydrogel composition.

The present invention relates to a pharmaceutical composition comprising an agent for enhancing peroxisomes for use for treatment of a condition associated with alpha-1-antitrypsin deficiency (AATD).

The present invention relates to a method for transferring a two-spin order of a molecule (e.g. parahydrogen) into a hyperpolarization of at least one heteronucleus, the method comprising the steps of: providing a molecule (e.g. parahydrogen pH₂) comprising two protons and at least one heteronucleus (S₃, S₄), the protons having nuclear spins being coupled to a nuclear spin of the at least one heteronucleus; exposing the protons and the at least one heteronucleus to an e.g. homogeneous magnetic field (B₀) in a z-direction, the z-direction forming a right-handed orthogonal coordinate system with an x- and a y-direction; and applying a sequence of radio frequency pulses to the protons and the at least one heteronucleus in order to transfer said two-spin order into the hyperpolarization of the at least one heteronucleus, wherein said sequence of radio frequency pulses comprises a first, a second, and a third group (N_A, N_B, N_C) of 180° radio frequency pulses, wherein the first group (N_A) of 180° radio frequency pulses is consecutively applied n_A times during a first time interval (τ_A) and wherein the second group (N_B) of 180° radio frequency pulses is consecutively applied n_B times during a second time interval (τ_B) after the last first group, and wherein the third group (N_C) of 180° radio frequency pulses is consecutively applied n_C times during a third time interval (τ_C) after the last second group, wherein n_A, n_B, n_C are integer numbers, respectively.

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