Tohoku University Patente

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The present invention provides an anti-CCR9 antibody or antigen binding fragment thereof comprising a variable light chain comprising SEQ ID NO:1 or a variant thereof having at least 95% sequence identity to SEQ ID NO:1, wherein the variable light chain comprises a CDR-L1 comprising the amino acid sequence RSSQSLXHSNGXTFLH (SEQ ID NO: 2), a CDR-L2 comprising the amino acid sequence KVSNRFS (SEQ ID NO: 3) and a CDR-L3 comprising the amino acid sequence SQTTHXPWT (SEQ ID NO: 4), wherein X can be any amino acid. Also provided is the anti-CCR9 antibody or antigen binding fragment thereof for use in the treatment or prevention of a disease, as well as methods of diagnosis and antibody drug conjugates.

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A model checking device includes a model acquisition unit configured to acquire a state transition model representing state transitions between a plurality of components, a local mathematical feature acquisition unit configured to acquire one or more predetermined local mathematical features associated with each of the plurality of components, a global mathematical feature calculation unit configured to calculate one or more global mathematical features associated with the state transition model based on the local mathematical features associated with the plurality of components, and a checking unit configured to perform model checking on the state transition model based on the one or more global mathematical features.

The present invention concerns an overcurrent protection device for a circuit to be monitored, having at least one trigger unit, which is configured for an interruption of the circuit in at least one trigger situation and which comprises at least one conductor section (40) which is configured for a conduction of a current to be monitored, at least one conductive trigger element (30, 31, 32), which comprises at least one thermo magnetically-shiftable material configured for a magnetic property change in dependence on the temperature induced by a current that flows through the conductor section, a conductive magnetic module (20, 21), a conductive magnetic core (10), said conductive magnetic module being movable between a first position faced against said conductive trigger element permitting the conduction of the current through the conductor section and a second position faced against said conductive magnetic core breaking the conduction of the current through the conductor section.

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The present invention correctly synchronizes and drives a plurality of external devices connected in parallel. A FPGA 30 is provided with a delay control circuit for delaying PWMs 1, 2, 3 on the basis of Syncs 1, 2, 3. The delay control circuit comprises: a phase difference detection circuit 40 (phase difference detection unit) for detecting a phase difference between the Syncs 1, 2, 3 (input signals), which are inputted from a gate driver/SiC 100; a phase difference time measurement circuit 50 (phase difference time measurement unit) for measuring a phase difference time of the phase difference detected by the phase difference detection circuit 40; a correction rate integration circuit 60 (integration unit) for calculating an integrated value by adding or subtracting the previous phase difference time to or from the current phase difference time measured by the phase difference time measurement circuit 50; a delay time determination circuit 70 (delay time determination unit) for determining a delay time of the PWMs 1, 2, 3 (output signals) on the basis of the integrated value calculated by the correction rate integration circuit 60; and a delay circuit 80 (delay unit) for delaying the PWMs 1, 2, 3 on the basis of the determined delay time.

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A high-frequency irradiation means (101) irradiates liquid (122) contained in a container (121) with high-frequency electromagnetic waves. A supply means (102) supplies raw material to the liquid (122). A frequency measurement means (103) measures a frequency of the high-frequency electromagnetic waves irradiated by the high-frequency irradiation means (101). A control means (104) controls the supply of raw material by the supply means (102) in accordance with the rate of change of a reference value, the reference value being based on maximum and minimum amplitude values for each cycle period for the frequency measured by the frequency measurement means (103).

A copper alloy has a composition containing 15% by mass or more and 57% by mass or less of Zn and containing 12% by mass or less of Al, in which, when a contained amount of Zn is denoted by A% by mass and a contained amount of Al is denoted by B% by mass, A + 5 × B ≥ 30 and A + 3.5 × B ≤ 57 are satisfied, and a balance is Cu and inevitable impurities, in which a volume fraction of a β phase is 50% or more, and when measurement is performed by an EBSD method on a measurement area of 8 mm<2> or more at a step size of 8 µm, and measurement points are analyzed by data analysis software OIM, excluding measurement points having a CI value of 0.1 or less, a crystal grain boundary is defined between adjacent measurement points with a misorientation of 5° or more, and a proportion of coincidence site lattice grain boundary length of 3 < Σ ≤ 29 to a total length of all crystal grain boundaries at which measured β phases are in contact with each other is 4% or more, where the copper alloy has excellent conductive properties, has a low Young's modulus and a sufficiently large elastic deformation amount, and is unlikely to undergo plastic deformation even in a case of receiving large deformation.

A copper alloy has a composition containing 15% by mass or more and 57% by mass or less of Zn and containing 12% by mass or less of Al, in which, when a contained amount of Zn is denoted by A% by mass and a contained amount of Al is denoted by B% by mass, A + 5 × B ≥ 30 and A + 3.5 × B ≤ 57 are satisfied, and a balance is Cu and inevitable impurities, in which a volume fraction of a β phase is 50% or more, and when measurement is performed by an EBSD method on a measurement area of 1 mm<2> or more at a step size of 1 µm, an average value of Kernel Average Misorientation (KAM) values of the β phase, which is measured by excluding measurement points for which a CI value analyzed by data analysis software OIM is 0.1 or less, is 2.0° or less, where the copper alloy has excellent conductive properties, has a low Young's modulus and a sufficiently large elastic deformation amount, and is unlikely to undergo plastic deformation even in a case of receiving large deformation.

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[Problem] To provide a fluid injection device capable of efficiently administering a drug. [Solution] A first transport body 11 includes a first transport flow path through which a first fluid 21 flows, and a second transport body 12 includes a second transport flow path through which a second fluid 22 flows. A positive-side microneedle 13 has a first opening and a first flow path having a fixed positive charge, and is provided in the first transport body 11. A negative-side microneedle 14 has a second opening and a second flow path having a fixed negative charge, and is provided in the second transport body 12. The current/voltage application means 15 is configured so as to be capable of applying a current or voltage between the first electrode 24 disposed in the first transport flow path and the second electrode 25 disposed in the second transport flow path. When a current or voltage is applied, an ionic current flows through the first fluid 21 and the second fluid 22, and due to electroosmotic flow, the first fluid 21 flows outward from the first opening, and the second fluid 22 flows outward from the second opening.

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